Calnexin Antibody (1563)

Calnexin, an abundant approx. 90kDa integral protein of the endoplasmic reticulum, is also referred to as IP90, p88 and p90 (1). It consists of a large 50kDa N-terminal calcium-binding luminal domain, a single transmembrane helix and a short acidic cytoplasmic tail (2, 3). Unlike its ER counterparts which have a KDEL sequence on their Cterminus to ensure ER retention (4), calnexin has positively charged cytosolic residues that do the same thing (3). Most ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into mulit-subunit proteins. Calnexin together with calreticulin, plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their monoglycosylated glycans (5, 6). Calnexin has also been shown to associate with the major histocompatability complex class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin (7).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 5 of 5.

Publications using NBP2-43765	Applications	Species
Müller-Calleja N, Hollerbach A, Canisius A et al. Rapid translocation of intracellular toll-like receptors depends on endosomal NADPH oxidase European journal of immunology 2023-06-27 [PMID: 37366283]
Copperi F, Schleis I, Roumain M et al. EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes Communications biology 2022-03-29 [PMID: 35351968] (WB, Mouse)	WB	Mouse
Ruhen O, Qu X, Jamaluddin MFB Et al. Dynamic Landscape of Extracellular Vesicle-Associated Proteins Is Related to Treatment Response of Patients with Metastatic Breast Cancer Membranes 2021-11-16 [PMID: 34832109] (WB, Human)	WB	Human
Ruhen O, Mirzai B, Clark ME et al. Comparison of Circulating Tumour DNA and Extracellular Vesicle DNA by Low-Pass Whole-Genome Sequencing Reveals Molecular Drivers of Disease in a Breast Cancer Patient Biomedicines 2020-12-25 [PMID: 33375577] (WB, Human)	WB	Human
Tiedemann K, Le Nihouannen D, Fong JE et al. Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt Front Cell Dev Biol. 2017-05-17 [PMID: 28573133] (WB, Mouse)	WB	Mouse

Array NBP2-43765

• Calnexin Antibodies
• Calnexin ELISA Kits
• Calnexin Lysates
• Calnexin Proteins