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Calcium-sensing R/CaSR Antibody (5C10, ADD) [DyLight 650]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Po, BvSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC
Clone
5C10, ADD
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 650

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB120-19347AF350
Alexa Fluor 405
NB120-19347AF405
Alexa Fluor 488
NB120-19347AF488
Alexa Fluor 532
NB120-19347AF532
Alexa Fluor 594
NB120-19347AF594
Alexa Fluor 647
NB120-19347AF647
Alexa Fluor 700
NB120-19347AF700
Alexa Fluor 750
NB120-19347AF750
Allophycocyanin
NB120-19347APC
Biotin
NB120-19347B
DyLight 350
NB120-19347UV
DyLight 405
NB120-19347V
DyLight 488
NB120-19347G
DyLight 550
NB120-19347R
DyLight 594
NB120-19347DL594
DyLight 680
NB120-19347FR
DyLight 755
NB120-19347IR
FITC
NB120-19347F
HRP
NB120-19347H
Janelia Fluor 525
NB120-19347JF525
Janelia Fluor 549
NB120-19347JF549
Janelia Fluor 646
NB120-19347JF646
Janelia Fluor 669
NB120-19347JF669
PE
NB120-19347PE
PerCP
NB120-19347PCP
Unconjugated
NB120-19347
mFluor Violet 450 SE
NB120-19347MFV450
mFluor Violet 500 SE
NB120-19347MFV500
mFluor Violet 610 SE
NB120-19347MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB120-19347
BSA Free
NB120-19347SS
BSA Free
NB120-19347
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Calcium-sensing R/CaSR Antibody (5C10, ADD) [DyLight 650] Summary

Immunogen
Partial synthetic peptide corresponding to residues 214 - 235 of human calcium sensing receptor R / CaSR [UniProt P41180]
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
CASR
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 21969374). Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information. Porcine reactivity reported in scientific literature (PMID: 27836810).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Calcium-sensing R/CaSR Antibody (5C10, ADD) [DyLight 650]

  • calcium-sensing receptor
  • CAR
  • CaSR
  • EIG8
  • extracellular calcium-sensing receptor
  • FHH
  • FIH
  • GPRC2A
  • GPRC2AHHC
  • HHC1
  • hypocalciuric hypercalcemia 1
  • NSHPT
  • parathyroid Ca(2+)-sensing receptor 1
  • Parathyroid cell calcium-sensing receptor
  • PCaR1
  • PCAR1MGC138441

Background

Calcium-Sensing Receptor (CaSR) is a member of the G protein-coupled receptor family. CaSR is an integral membrane protein that senses changes in the extracellular concentration of calcium ions and controls the release of parathyroid hormone. The activity of the calcium-sensing receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Mutations that inactivate CaSR lead to familial hypocalciuric hypercalcemia, whereas mutations that activate CaSR cause autosomal dominant hypocalcemia. Calcium-Sensing Receptor antibodies are useful tools for parathyroid studies and research on cellular calcium homeostasis regulation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CASR