BTK [p Tyr223] Antibody (720101)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Bruton tyrosine kinase (BTK) is a 75 kDa cytoplasmic protein tyrosine kinase that is widely expressed in hematopoietic cells. BTK is required for B cell receptor signaling and B cell development. Defects in BTK result in X-linked agammaglobulinemia which is characterized by a severely decreased level of circulating antibodies. Like other Tec family kinases, BTK contains a Pleckstrin homology domain, a Tec homology domain, an SH3 domain, an SH2 domain, and a protein kinase domain. Association of the BTK SH2 domain with the B cell linker protein (BLNK) is required for the activation of PLC gamma by BTK. The autophosphorylation of Tyr223 facilitates the interaction of BTK with activated Syk. The sequence used as a peptide immunogen is identical in human, mouse and rat BTK.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB7205

• BTK Antibodies
• BTK ELISA Kits
• BTK Lysate
• BTK Proteins