BRCA1 Antibody (6B4)

BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full length natures identified.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 5 applications: Chemotaxis, ICC/IF, IF/IHC, Immunohistochemistry, WB.

Showing Publications 1 - 9 of 9.

Publications using NB100-404	Applications	Species
Di Agostino S, Canu V, Donzelli S et al. HSF-1/miR-145-5p transcriptional axis enhances hyperthermic intraperitoneal chemotherapy efficacy on peritoneal ovarian carcinosis Cell death & disease 2023-08-19 [PMID: 37598177] (Immunohistochemistry, Human)	Immunohistochemistry	Human
Wei YS, Chen YL, Li WY et al. Antioxidant Nanoparticles Restore Cisplatin-Induced Male Fertility Defects by Promoting MDC1-53bp1-Associated Non-Homologous DNA Repair Mechanism and Sperm Intracellular Calcium Influx International Journal of Nanomedicine 2023-08-07 [PMID: 37576465]
Swift M, Azizkhan-Clifford J DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR DNA Repair 2022-02-01 [PMID: 35124373] (Chemotaxis, ICC/IF, Human)	Chemotaxis, ICC/IF	Human
Swift ML, Beishline K, Flashner S, Azizkhan-Clifford J DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1 Cell reports 2021-03-16 [PMID: 33730584] (ICC/IF, Chemotaxis)	ICC/IF, Chemotaxis
Zhai B, Li Y, Kotapalli SS et al. Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells Cell Death Dis 2020-07-24 [PMID: 32709853] (WB, Human)	WB	Human
Zhai B, Steino A, Bacha J et al. Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination. Cell Death Dis. 2018-10-03 [PMID: 30283085] (WB, Human)	WB	Human
Berger AK, Cortese GP, Amodeo KD et al. Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release. Hum Mol Genet;18(22):4317-28. 2009-11-15 [PMID: 19679562]
Bernard-Gallon DJ, Dechelotte PJ, Le Corre L et al. Differential expressions of BRCA1 and BRCA2 in infantile gynecomastia. Anticancer Res 2004-01-01 [PMID: 15015615] (IF/IHC, Human)	IF/IHC	Human
Li S, Ting NS, Zheng L et al. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 2000-07-01 [PMID: 10910365] (IF/IHC, Human)	IF/IHC	Human

Array NB100-404

• BRCA1 Antibodies
• BRCA1 Antibody Pack
• BRCA1 ELISA Kits
• BRCA1 Proteins