BORIS Antibody

BORIS (Brother of the Regulator of Imprinted Sites) also known as CCTC-binding factor-like protein, is normally only expressed in the testis and expressed in a mutually exclusive manner with CTCF during male germ cell development. However, previous studies have shown that BORIS is abnormally activated in a wide range of human cancers. Expression of BORIS in normally BORIS-negative cells promotes cell growth that may lead to transformation. BORIS maps to the cancer-associated amplification region thought to contain an oncogene or dominant-immortalizing gene. BORIS is a candidate protein for the epigenetic reprogramming factor acting in the male germ line. BORIS is found in both the nucleus and cytoplasm.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IF/IHC.

Showing Publications 1 - 3 of 3.

Publications using NBP1-89947	Applications	Species
Freitas MR, Malheiros SM, Stavale JN et al. Expression of Cancer/Testis Antigens is Correlated with Improved Survival in Glioblastoma. Oncotarget 2013-04-01 [PMID: 23592437] (IF/IHC, Human)	IF/IHC	Human
Jones TA, Ogunkolade BW, Szary J et al. Widespread expression of BORIS/CTCFL in normal and cancer cells. PLoS One 2011-01-01 [PMID: 21811597]
Hines WC, Bazarov AV, Mukhopadhyay R et al. BORIS (CTCFL) is not expressed in most human breast cell lines and high grade breast carcinomas. PLoS One 2010-03-01 [PMID: 20305816]

Array NBP1-89947

• BORIS Antibodies
• BORIS Lysate
• BORIS Proteins