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BMPR-IB/ALK-6 Antibody (477914) [Phycoerythrin]

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PC-3 human prostate cancer cell line was stained with Mouse Anti-Human BMPR-IB/ALK-6 PE-conjugated Monoclonal Antibody (Catalog # FAB5051P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.
PC-3 human prostate cancer cell line was stained with Mouse Anti-Human BMPR-IB/ALK-6 PE-conjugated Monoclonal Antibody (Catalog # FAB5051P, filled histogram) or isotype control antibody (Catalog # IC0041P, open ...read more
Human iPS cells differentiated to mesoderm (using Catalog # SC030B) were stained with Mouse Anti-Human BMPR-IB/ALK-6 PE-conjugated Monoclonal Antibody (Catalog # FAB5051P, filled histogram) or isotype control antibody ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
477914
Clonality
Monoclonal
Host
Mouse
Conjugate
Phycoerythrin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB5051U-100UG
Alexa Fluor 405
FAB5051V-100UG
Alexa Fluor 488
FAB5051G-100UG
Alexa Fluor 532
FAB5051X
Alexa Fluor 594
FAB5051T-100UG
Alexa Fluor 647
FAB5051R-100UG
Alexa Fluor 700
FAB5051N-100UG
Alexa Fluor 750
FAB5051S-100UG
Allophycocyanin
FAB5051A
Allophycocyanin/Cy7
FAB5051APCCY7
Biotin
FAB5051B
CoraFluor 1
FAB5051CL1
DyLight 350
FAB5051D
DyLight 405
FAB5051E
DyLight 488
FAB5051K
DyLight 550
FAB5051L
DyLight 594
FAB5051M
DyLight 650
FAB5051W
DyLight 680
FAB5051Y
DyLight 755
FAB5051Z
FITC
FAB5051F
HRP
FAB5051H
Janelia Fluor 525
FAB5051JF525
Janelia Fluor 549
FAB5051I
Janelia Fluor 646
FAB5051J
Janelia Fluor 669
FAB5051JF669
PE/Atto594
FAB5051PEATT594
PE/Cy5.5
FAB5051PECY55
PE/Cy7
FAB5051PECY7
PerCP
FAB5051C
Unconjugated
MAB5051
mFluor Violet 450 SE
FAB5051MFV450
mFluor Violet 500 SE
FAB5051MFV500
mFluor Violet 610 SE
FAB5051MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB5051
Carrier Free
MAB5051
Carrier Free
FAB5051A
Carrier Free
MAB5051-SP
Carrier Free
FAB5051V-100UG
Carrier Free
FAB5051U-100UG
Carrier Free
FAB5051T-100UG
Carrier Free
FAB5051S-100UG
Carrier Free
FAB5051R-100UG
Carrier Free
FAB5051N-100UG
Carrier Free
FAB5051G-100UG
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BMPR-IB/ALK-6 Antibody (477914) [Phycoerythrin] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human BMPR‑IB/ALK‑6
Lys14-Arg126
Accession # O00238
Specificity
Detects human BMPR‑IB/ALK‑6 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse BMPR-IB is observed.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
BMPR1B
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells
Publications
Read Publications using
FAB5051P in the following applications:

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BMPR-IB/ALK-6 Antibody (477914) [Phycoerythrin]

  • activin receptor-like kinase 6
  • ALK-6
  • ALK6CDw293
  • BMP type-1B receptor
  • BMPR1B
  • BMPR-1B
  • BMPRIB
  • BMPR-IB
  • bone morphogenetic protein receptor type-1B
  • bone morphogenetic protein receptor, type IB
  • CDw293 antigen
  • CDw293
  • EC 2.7.11
  • EC 2.7.11.30
  • serine/threonine receptor kinase

Background

Cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the formation of hetero-oligomeric complexes of the type I and type II serine/threonine kinase receptors. BMP receptor IB (BMPR-IB), also known as activin receptor-like kinase (ALK)-6, is one of seven known type I serine/threonine kinases that are required for the signal transduction of TGF-beta family cytokines. In contrast to the TGF-beta receptor system in which the type I receptor does not bind TGF-beta in the absence of the type II receptor, type I receptors involved in BMP signaling (including BMPR-IA, BMPR-IB/ALK-6, and ActR-I/ALK-2) can independently bind the various BMP family proteins in the absence of type II receptors. Recombinant soluble BMPR-IB binds BMP-4 with high-affinity in solution and is a potent BMP-4 antagonist in vitro. BMPR-IB is expressed in various tissues during embryogenesis. In adult tissues, BMPR-IB is only found in the brain. The extracellular domain of BMPR-IB shares little amino acid sequence identity with the other mammalian ALK type I receptor kinases, but the cysteine residues are conserved. Human and mouse BMPR-IB are highly conserved and share 98% amino acid sequence identity.

  1. Kawabata, M. et al. (1998) Cytokine and Growth Factor Reviews 9:49.
  2. Ebendal, T. et al. (1998) J. Neuroscience Research 51:139.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for BMPR-IB/ALK-6 Antibody (FAB5051P)(4)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Cell Selection, Flow Cytometry.


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Cell Selection
(1)
Flow Cytometry
(2)
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(3)
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Bioinformatics

Gene Symbol BMPR1B
Uniprot