Bcl-xL Antibody (2052A) [Unconjugated]

Bcl-x_L is a member of the Bcl-2 family of proteins that regulates outer mitochondrial membrane permeability (1, 2). Bcl-x_L is an anti-apoptotic member that prevents release of cytochrome c from the mitochondria intermembrane space into the cytosol. Bcl-x_L is present on the outer mitochondrial membrane and is also found on other membranes in some cell types. Natural Bcl-x_L contains a carboxyl-terminal mitochondria targeting sequence. Recombinant Bcl-x_L missing the mitochondrial targeting sequence maintains its ability to neutralize pro-apoptotic Bcl-2 family members. Neutralization by Bcl-x_L appears to be mediated through binding the BH3 region of pro-apoptotic Bcl-2 family members. This activity does not require the mitochondrial targeting sequence.

• Bcl-xL Antibodies
• Bcl-xL ELISA Kit
• Bcl-xL Lysates
• Bcl-xL Proteins
• Bcl-xL Proteins and Enzymes
• Bcl-xL ELISA