| Reactivity | Hu, MuSpecies Glossary |
| Applications | Flow, ICC/IF, IHC |
| Clone | SPM602 |
| Clonality | Monoclonal |
| Host | Mouse |
| Conjugate | DyLight 405 |
| Immunogen | Recombinant human bcl-6 protein (Uniprot: P41182) |
| Localization | Nuclear |
| Marker | Follicular Lymphoma Marker |
| Specificity | Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ('LH') cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma. |
| Isotype | IgG1 Kappa |
| Clonality | Monoclonal |
| Host | Mouse |
| Gene | BCL6 |
| Purity | Protein A or G purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Dilutions |
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| Application Notes | Optimal dilution of this antibody should be experimentally determined. |
| Storage | Store at 4C in the dark. |
| Buffer | 50mM Sodium Borate |
| Preservative | 0.05% Sodium Azide |
| Purity | Protein A or G purified |
![Immunohistochemistry CD3 Antibody (17A2) [Unconjugated]](https://images.novusbio.com/images2/CD3_MAB4841_Immunohistochemistry_7033.jpg)
![Immunocytochemistry CD3 Antibody (17A2) [Unconjugated]](https://images.novusbio.com/images2/CD3_MAB4841_Immunocytochemistry__Immunofluorescence_23528.jpg)
![Immunohistochemistry CD3 Antibody (17A2) [Unconjugated]](https://images.novusbio.com/images/antibody/mab4841_mouse-cd3-mab-clone-17a2-immunohistochemistry-88202312119.jpg)
![Bcl-6 Antibody (SPM602) [DyLight 405]](/sites/all/modules/enterprise-tech/et_datasheets/images/novus_guarantee.png "Bcl-6 Antibody (SPM602) [DyLight 405]")
Secondary Antibodies |
Isotype Controls |
Research Areas for Bcl-6 Antibody (NBP3-08851V)Find related products by research area.
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| Gene Symbol | BCL6 |
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![Flow Cytometry: Mouse IgG1 Kappa Isotype Control (P3.6.2.8.1) [NBP1-43319] - Analysis of Alexa Fluor (R) 700 conjugate of NBP1-43319. Human buffy coat stained with mouse IgG1 Kappa isotype control. Flow cytometry image submitted by a verified customer review.](https://images.novusbio.com/images/Mouse-IgG1-Kappa-Light-Chain-Isotype-Control-P3-6-2-8-1-Flow-Cytometry-NBP1-43319-img0002.jpg "Flow Cytometry: Mouse IgG1 Kappa Isotype Control (P3.6.2.8.1) [NBP1-43319] - Analysis of Alexa Fluor (R) 700 conjugate of NBP1-43319. Human buffy coat stained with mouse IgG1 Kappa isotype control. Flow cytometry image submitted by a verified customer review.")