BACH1 Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

BACH1 (BTB and CNC homolog 1; also basic leucine zipper transcription factor 1) is a ubiquitously expressed member of the Bach family of transcription factors. Although its predicted MW is 82 kDa, it runs anomalously at 110 kDa in SDS-PAGE. BACH1 forms non‑covalent homodimers, and heterodimers with Maf oncoproteins and p53-related proteins. It apparently serves as an architectural component for gene regulatory protein complexes. Human BACH1 is 736 amino acids (aa) in length. It contains a protein-interaction BTB domain (aa 24‑127), a DNA-binding motif (aa 562‑577), and a Leu-zipper domain (aa 585‑607). This molecule should not be confused with Bach1/Fancj/Brip1 helicase. There are two BACH1 splice variants with a 24 and 31 aa substitution for aa 593‑736, respectively. Over aa 133‑513, human BACH1 shares 75% aa identity with mouse BACH1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: ChIP, Immunoprecipitation, Western Blot.

Showing Publications 1 - 8 of 8.

Publications using AF5776	Applications	Species
He, Y;Guo, J;Yu, Y;Jin, J;Jiang, Q;Li, Q;Ma, S;Pan, Q;Lin, J;Jiang, N;Ma, J;Li, Y;Hou, Y;Zhi, X;Jiang, L;Qu, L;Osto, E;Wang, X;Wei, X;Meng, D; BACH1 regulates the differentiation of vascular smooth muscle cells from human embryonic stem cells via CARM1-mediated methylation of H3R17 Cell reports 2023-11-21 [PMID: 37995178] (Western Blot, Human)	Western Blot	Human
X Xie, L Tian, Y Zhao, F Liu, S Dai, X Gu, Y Ye, L Zhou, X Liu, Y Sun, X Zhao BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids Oncogene, 2023-01-20;14(1):48. 2023-01-20 [PMID: 36670112] (ChIP, Human)	ChIP	Human
J Padilla, BS Lee, K Zhai, B Rentz, T Bobo, NM Dowling, J Lee A Heme-Binding Transcription Factor BACH1 Regulates Lactate Catabolism Suggesting a Combined Therapy for Triple-Negative Breast Cancer Cells, 2022-03-31;11(7):. 2022-03-31 [PMID: 35406740] (Immunoprecipitation, Human)	Immunoprecipitation	Human
Y Zhao, J Gao, X Xie, P Nan, F Liu, Y Sun, X Zhao BACH1 promotes the progression of esophageal squamous cell carcinoma by inducing the epithelial-mesenchymal transition and angiogenesis Cancer Medicine, 2021-05-01;0(0):. 2021-05-01 [PMID: 33932125] (ChIP, Human)	ChIP	Human
J Xu, H Guo, Z Xing, W Zhang, J He, J Cheng, R Cai Mild Oxidative Stress Reduces NRF2 SUMOylation to Promote Kras/Lkb1/Keap1 Mutant Lung Adenocarcinoma Cell Migration and Invasion Oxidative Medicine and Cellular Longevity, 2020-11-24;2020(0):6240125. 2020-11-24 [PMID: 33299528] (Western Blot, Human)	Western Blot	Human
X Wei, J Guo, Q Li, Q Jia, Q Jing, Y Li, B Zhou, J Chen, S Gao, X Zhang, M Jia, C Niu, W Yang, X Zhi, X Wang, D Yu, L Bai, L Wang, J Na, Y Zou, J Zhang, S Zhang, D Meng Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cells Sci Adv, 2019-03-13;5(3):eaau7887. 2019-03-13 [PMID: 30891497] (Western Blot, Human)	Western Blot	Human
J Lee, AE Yesilkanal, JP Wynne, C Frankenber, J Liu, J Yan, M Elbaz, DC Rabe, FD Rustandy, P Tiwari, EA Grossman, PC Hart, C Kang, SM Sanderson, J Andrade, DK Nomura, MG Bonini, JW Locasale, MR Rosner Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism Nature, 2019-03-06;0(0):. 3/6/2019 [PMID: 30842661]
Attucks , Otis C, Jasmer , Kimberly, Hannink , Mark, Kassis , Jareer, Zhong , Zhenping, Gupta , Suparna, Victory , Sam F, Guzel , Mustafa, Polisetti , Dharma R, Andrews , Robert, Mjalli , Adnan M, Kostura , Matthew Induction of heme oxygenase I (HMOX1) by HPP-4382: a novel modulator of Bach1 activity. PLoS ONE, 2014-07-14;9(7):e101044. 2014-07-14 [PMID: 25019514] (Immunoprecipitation, Human)	Immunoprecipitation	Human

Array AF5776

• BACH1 Antibodies
• BACH1 ELISA Kit
• BACH1 Lysates
• BACH1 Proteins