Apolipoprotein E/ApoE Antibody - BSA Free

The apolipoproteins are family of amphipathic lipoproteins that plays a crucial role in lipid metabolism. In particular, apolipoprotein E (apo E) is a major component of high density lipoproteins (HDL) chylomicrons and very low-density lipoprotein (VLDL), which functions to remove excess cholesterol. Apo E mediates lipid metabolism and cholesterol homeostasis by binding to several hepatic lipoprotein receptors, such as low density lipoprotein receptor (LDLR) and the LDLR-related protein (1). Apo E deficiency is linked to hyperlipoproteinemia type III; a genetic disorder characterized by elevated plasma cholesterol and triglyceride levels and accelerated coronary artery disease (2). Three major isoforms of Apo E (E2, E3, E4) has been identified, with E3 being the most common in human. E4 presence has been associated to increase probability of developing late-onset form of Alzheimer disease (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 4 applications: Block/Neutralize, Simple Western, WB, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using NBP1-31123	Applications	Species
Rosemary J Jackson, Megan S Keiser, Jonah C Meltzer, Dustin P Fykstra, Steven E Dierksmeier, Soroush Hajizadeh, Johannes Kreuzer, Robert Morris, Alexandra Melloni, Tsuneo Nakajima, Luis Tecedor, Paul T Ranum, Ellie Carrell, YongHong Chen, Maryam A Nishtar, David M Holtzman, Wilhelm Haas, Beverly L Davidson, Bradley T Hyman APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease. Molecular therapy : the journal of the American Society of Gene Therapy 2024-03-19 [PMID: 38504517]
Carrell EM, Chen YH, Ranum PT et al. VWA3A-derived ependyma promoter drives increased therapeutic protein secretion into the CSF Molecular Therapy - Nucleic Acids 2023-09-12 [PMID: 37547292] (Simple Western)	Simple Western
Jackson RJ, Meltzer JC, Nguyen H et al. APOE4 derived from astrocytes leads to blood-brain barrier impairment Brain 2022-10-21 [PMID: 34957486] (Western Blot, Block/Neutralize)	Western Blot, Block/Neutralize
Cunningham M Establishing the Freestyle 293 Expression System as a Tool to Generate Recombinant Apolipoprotein E in Mammalian Cells Thesis 2022-01-01 (WB, Human, Rat) Details: Dilution used for WB 1:5000	WB	Human, Rat

Array NBP1-31123

• Apolipoprotein E/ApoE Antibodies
• Apolipoprotein E/ApoE ELISA Kits
• Apolipoprotein E/ApoE Lysate
• Apolipoprotein E/ApoE Protein