Orthogonal Strategies: Immunohistochemistry-Paraffin: AlphaB Crystallin/CRYAB Antibody [NBP2-49246] - Analysis in human heart muscle and liver tissues using NBP2-49246 antibody. Corresponding CRYAB RNA-seq data ...read more
Immunohistochemistry-Paraffin: AlphaB Crystallin/CRYAB Antibody [NBP2-49246] - Staining of human liver shows very weak cytoplasmic positivity in hepatocytes.
Immunohistochemistry-Paraffin: AlphaB Crystallin/CRYAB Antibody [NBP2-49246] - Staining of human heart muscle shows strong cytoplasmic positivity in cardiomyocytes.
Immunohistochemistry-Paraffin: AlphaB Crystallin/CRYAB Antibody [NBP2-49246] - Staining of human skeletal muscle shows moderate ctyoplasmic positivity in myocytes.
Immunohistochemistry-Paraffin: AlphaB Crystallin/CRYAB Antibody [NBP2-49246] - Staining of human pancreas shows very weak cytoplasmic positivity in exocrine glandular cells.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for AlphaB Crystallin/CRYAB Antibody
alpha B crystallin
alpha(B)-crystallin
AlphaB Crystallin
alpha-crystallin B chain
CRYA2
CRYA2alpha crystallin B chain
CRYAB
crystallin, alpha B
CTPP2
Heat shock protein beta-5
heat-shock 20 kD like-protein
HSPB5
Renal carcinoma antigen NY-REN-27
Rosenthal fiber component
Background
Crystallin AB is a member of the small heat shock protein family and expressed in several tissues including brain, kidney cardiac and skeletal muscle. Crystallin AB functions as a molecular chaperone and in intracellular architecture. Crystallin AB has shown to have interactions with CRYAA, CRYGC, CRYBB2, CRYBA1 and HSPB8. Defects in crystalline AB have been linked to cause myopathy myofibrillar type 2, cataract posterior polar type 2, and myopathy myofibrillar fatal infantile hypertonic alpha-B crystallin-related (MFMFIH-CRYAB).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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