Independent Antibodies: Western Blot: AKAP13 Antibody [NB100-68214] - Detection of Human AKAP13/AKAP-Lbc on HeLa whole cell lysate using NB100-68214. AKAP13/AKAP-Lbc was also immunoprecipitated by rabbit ...read more
The immunogen recognized by this antibody maps to a region between residue 2754 and 2804 of human A kinase (PRKA) anchor protein 13 using the numbering given in entry NP_009131.2 (GeneID 11214).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
AKAP13
Purity
Immunogen affinity purified
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Lymphoid blast crisis oncogeneProtein kinase A-anchoring protein 13
p47
PROTO-LB
PROTO-LBC
Background
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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