Adenylate Cyclase 3 Antibody

The biosynthesis of cAMP/cyclic 3'5'-AMP from ATP is catalyzed by adenylyl cyclases (ADCYs or ACs) which are a groups of enzymes having about ten closely related isoforms including ADCYs 1-9 and ADCYAP1 (ADCY activating polypeptide 1). Adenylate Cyclase 3 (ADCY3 or AC3) is third member of ADCYs family which is a membrane-associated enzyme and catalyzes the formation of secondary messenger cAMP. ADCY3 enzyme is localized in the membranes surrounding cilia in neurons, and is considered an excellent marker of neuronal cilia in brain tissues or in cell culture. Human ADCY3 is a large complex molecule of 1145 amino acids with an expected molecular weight of 129kD and due to extensive glycosylation, a diffused band of about 160kD in cortex and about 200kD in olfactory epithelium is generally observed in Western blots. ADCY3 appears to be widely expressed in various human tissues wherein it implicates in a number of physiological (including odorant detection via controlling intracellular cAMP levels) as well as pathophysiological metabolic processes. ADCY3 knock out mice exhibits obesity upon ageing primarily because of low locomoter activity, hyperphagia and leptin insensitivity. Moreover, ADCY3 genetic polymorphisms have been linked to decreased risk of body mass index/BMI among the subjects with obesity and type 2 diabetes/NIDDM suggesting that ADCY3 is a novel candidate in the regulation of body weight.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 3 applications: ICC/IF, IHC-Fr, WB.

Showing Publications 1 - 9 of 9.

Publications using NBP1-92683	Applications	Species
Hua K, Ferland R Fixation methods and immunolabeling for cilia proteins in ciliary and extraciliary locations Methods in Cell Biology 2023-02-24 [PMID: 37164542]
Rong-Chang Li, Laurie L. Molday, Chih-Chun Lin, Xiaozhi Ren, Alexander Fleischmann, Robert S. Molday, King-Wai Yau Low signaling efficiency from receptor to effector in olfactory transduction: A quantified ligand-triggered GPCR pathway Proceedings of the National Academy of Sciences of the United States of America 2022-08-01 [PMID: 35914143]
Wu X, Yang D, Zhou Y et al. The role of ciliopathy-associated type 3 adenylyl cyclase in infanticidal behavior in virgin adult male mice iScience 2022-07-15 [PMID: 35754726] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Son Y, Choi C, Saha A et al. REEP6 knockout leads to defective beta-adrenergic signaling in adipocytes and promotes obesity-related metabolic dysfunction Metabolism: clinical and experimental 2022-02-09 [PMID: 35150731] (ICC/IF, Mouse)	ICC/IF	Mouse
Yang D, Wu X, Wang W et al. Ciliary Type III Adenylyl Cyclase in the VMH Is Crucial for High-Fat Diet-Induced Obesity Mediated by Autophagy Advanced Science 2022-01-01 [PMID: 34783461]
Hampson E, Tsonou E, Baker MJ et al. P-Rex1 Controls Sphingosine 1-Phosphate Receptor Signalling, Morphology, and Cell-Cycle Progression in Neuronal Cells Cells 2021-09-18 [PMID: 34572121] (WB, Rat)	WB	Rat
Iwase, M, Tokiwa, S Et al. Glycerol kinase stimulates uncoupling protein 1 expression by regulating fatty acid metabolism in beige adipocytes. J Biol Chem 2020-05-15 [PMID: 32273338] (ICC/IF, Mouse)	ICC/IF	Mouse
Liu X, Zhou Y, Yang D et al. Type 3 adenylyl cyclase in the MOE is involved in learning and memory in mice Behavioural Brain Research 2020-02-01 [PMID: 32023491] (ICC/IF)	ICC/IF
Quinn SN, Graves SH, Dains-McGahee C et al. Adenylyl cyclase 3/adenylyl cyclase-associated protein 1 (CAP1) complex mediates the anti-migratory effect of forskolin in pancreatic cancer cells. Mol. Carcinog. 2016-11-27 [PMID: 27891679]

Array NBP1-92683

• Adenylate Cyclase 3 Antibodies
• Adenylate Cyclase 3 ELISA Kit
• Adenylate Cyclase 3 Lysate
• Adenylate Cyclase 3 Protein