Adenosylhomocysteinase/AHCY Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human S‑Adenosylhomocysteinase (AHCY) is a cytoplasmic tetramer with a tightly bound NAD co‑factor for each subunit (1, 2). It is the only known enzyme to catalyze the breakdown of S‑adenosylhomocysteine (AdoHcy) to homocysteine and adenosine. AdoHcy hydrolysis is a reversible reaction with an equilibrium favoring AdoHcy formation, but hydrolysis prevails under physiological conditions due to the rapid removal of adenosine and homocysteine. Thus, AHCY’s activity in mammals is directly related to homocysteine level, an independent risk factor for vascular disease (3). It also functions as a regulator of biological transmethylation by controlling the concentration of AdoHcy, a potent competitive inhibitor of all S‑adonosyl-L-methionine methyltransferases (1). A mutation in the human AHCY results in AHCY deficiency with increase of plasma creatine kinase, methionine, S‑adenosylmethionine and AdoHcy, delay of myelination, myopathy and psychomotor retardation (4, 5).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publication 1 - 1 of 1.

Publication using AF6466	Applications	Species
Barroso M, Florindo C, Kalwa H, Silva Z, Turanov A, Carlson B, de Almeida I, Blom H, Gladyshev V, Hatfield D, Michel T, Castro R, Loscalzo J, Handy D Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression. J Biol Chem, 2014-04-09;289(22):15350-62. 2014-04-09 [PMID: 24719327] (Western Blot, Human)	Western Blot	Human

Array AF6466

• Adenosylhomocysteinase/AHCY Antibodies
• Adenosylhomocysteinase/AHCY ELISA Kits
• Adenosylhomocysteinase/AHCY Lysate
• Adenosylhomocysteinase/AHCY Proteins
• Adenosylhomocysteinase/AHCY Proteins and Enzyme