Adenosine A1R Antibody - BSA Free

Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily. Structural, biochemical and pharmacological analyses of the AR genes and protein has led to the discovery of four distinct AR subtypes (A1, A2a, A2b, A3). Activation of ARs mediates several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission.The A1AR is a glycoprotein that can activate Gi and Go proteins in vitro. In intact cells, agonist occupation of the A1AR has been shown to cause pertussis toxin-sensitive inhibition of adenylyl cyclase activity and, in some systems, a stimulation of phospholipase C resulting in mobilization of intracellular calcium stores. Activation of potassium channels by A1AR has been intensively studied in relation to its dramatic effects on the cardiovascular system. A1AR protein is highly expressed in brain (especially cerebellum, hippocampus, thalamus, and cortex) and spinal cord and in part, modulates neurotransmitter release. In white adipocytes A1AR inhibits lipolysis and stimulates glucose uptake. Other tissues also express A1AR including kidney and testis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 7 applications: FLOW, ICC/IF, IF/IHC, IHC-Fr, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, WB.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NB300-549	Applications	Species
See LP, Sripinun P, Lu W et al. Increased Purinergic Signaling in Human Dental Pulps With Inflammatory Pain is Sex-Dependent The journal of pain 2023-11-11 [PMID: 37956743]
Schubert C, Schulz K, Tr�ger S et al. Neuronal Adenosine A(1) Receptor is Critical for Olfactory Function but Unable to Attenuate Olfactory Dysfunction in Neuroinflammation Frontiers in Cellular Neuroscience 2022-06-30 [PMID: 35846561] (Immunocytochemistry/ Immunofluorescence)	Immunocytochemistry/ Immunofluorescence
Dragi? M, Mitrovi? N, Ad�i? M et al. Microglial- and Astrocyte-Specific Expression of Purinergic Signaling Components and Inflammatory Mediators in the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration ASN Neuro 2021-09-27 [PMID: 34569324]
Pang L, Ng KT, Liu J et al. Plasmacytoid dendritic cells recruited by HIF-1 alpha /eADO/ADORA1 signaling induce immunosuppression in hepatocellular carcinoma Cancer letters 2021-09-16 [PMID: 34536555] (FLOW, Human)	FLOW	Human
Dragi? M, Zeljkovi? M, Stevanovi? I et al. Downregulation of CD73/A(2A)R-Mediated Adenosine Signaling as a Potential Mechanism of Neuroprotective Effects of Theta-Burst Transcranial Magnetic Stimulation in Acute Experimental Autoimmune Encephalomyelitis Brain Sciences 2021-06-01 [PMID: 34205965] (Immunohistochemistry)	Immunohistochemistry
Kutryb-Zajac B, Jablonska P, Serocki M et al. Extracellular Adenine Nucleotide and Adenosine Metabolism in Calcific Aortic Valve Disease. bioRxiv 2018-08-28 [PMID: 32126886] (ICC/IF, Human)	ICC/IF	Human
Kutryb-Zajac B, Mierzejewska P, Sucajtys-Szulc E et al. Inhibition of LPS-stimulated ecto-adenosine deaminase attenuates endothelial cell activation J. Mol. Cell. Cardiol. 2019-01-11 [PMID: 30641086] (ICC/IF, Human)	ICC/IF	Human
Hackett TA. Adenosine A1 Receptor mRNA Expression by Neurons and Glia in the Auditory Forebrain. Anat Rec (Hoboken). 2018-10-12 [PMID: 30315630] (IF/IHC, Mouse)	IF/IHC	Mouse
Ren ZH, Lin CZ, Cao W et al. CD73 is associated with poor prognosis in HNSCC. Oncotarget. 2016-09-20 [PMID: 27557512] (IF/IHC, WB, Human)	IF/IHC, WB	Human
Yamaguchi D, Terayama R, Omura S et al. Effect of adenosine A1 receptor agonist on the enhanced excitability of spinal dorsal horn neurons after peripheral nerve injury. Int J Neurosci. 2013-10-14 [PMID: 24016034] (IHC-Fr, Rat)	IHC-Fr	Rat
Yu, W, Zacharia, L C, Jackson, E K, Apodaca, G. Adenosine receptor expression function in bladder uroepithelium, . 291, C254-265. 2006-01-01 [PMID: 16571869]
Kimura M, Saitoh N, Takahashi T et al. Adenosine A(1) receptor-mediated presynaptic inhibition at the calyx of Held of immature rats. J Physiol. 2003-12-01 [PMID: 12963795]
Show All 12 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Bryan Tinsley	ICC	Rat	08/27/2014	View Summary Application Immunocytochemistry Species Rat

Array NB300-549

• Adenosine A1R Antibodies
• Adenosine A1R ELISA Kit
• Adenosine A1R Protein