Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Preservative
0.09% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Notes
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Activin RIB/ALK-4 Antibody (544310) [Alexa Fluor® 488]
activin A receptor, type IB
Activin receptor type IB
Activin receptor-like kinase 4
Activin RIB
ActivinRIB
ACTRIB
ACVR1B
ACVRLK4ACTR-IB
ALK4
ALK-4
ALK4activin A receptor, type II-like kinase 4
EC 2.7.11
EC 2.7.11.30
Serine/threonine-protein kinase receptor R2
SKR2activin receptor type-1B
Background
Activin RIB, also known as ALK4, is a glycosylated 58 kDa type I receptor in the superfamily of TGF-beta serine/threonine kinase receptors. Activin RIB associates with Activin RIIB to form a receptor complex for activin and inhibin molecules (1). These ligands bind to Activin RIIB which then associates with and phosphorylates the cytoplasmic domain of Activin RIB to initiate signal transduction (2, 3). Mature human Activin RIB consists of a 103 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 356 aa cytoplasmic region that includes the kinase domain (4). Within the ECD, human Activin RIB shares 93% and 95% aa sequence identity with mouse and rat Activin RIB, respectively. It shares 25-35% aa sequence identity with other human type I receptors Activin RIA, Activin RIC, BMPR-IA, BMPR-IB, and TGF-beta R1. Alternately spliced isoforms of Activin RIB have deletions in the cytoplasmic domain and function as dominant negative inhibitors of activin signaling (5, 6). Activin receptor signaling is modulated by the direct interaction of Activin RIB with cripto or inhibin binding protein (7-9). Activin RIB is excluded from the signaling complex if Activin RIIB first binds inhibin and betaglycan (10). Activin RIB functions in a wide variety of growth and differentiation processes, including embryonic cell fate and axis determination, cell proliferation and apoptosis, and tumorigenesis (1, 11, 12).
Chen, Y- G. et al. (2006) Exp. Biol. Med. 231:534.
Attisano, L. et al. (1996) Mol. Cell. Biol. 16:1066.
Tsuchida, K. et al. (1995) Endocrinology 136:5493.
ten Dijke, P. et al. (1993) Oncogene 8:2879.
Xu, J. et al. (1994) Proc. Natl. Acad. Sci. USA 91:7957.
Zhou, Y. et al. (2000) Mol. Endocrinol. 14:2066.
Chapman, S.C. and T.K. Woodruff (2001) Mol. Endocrinol. 15:668.
Bianco, C. et al. (2002) Mol. Cell. Biol. 22:2586.
Gray, P.C. et al. (2003) Proc. Natl. Acad. Sci. USA 100:5193.
Lewis, K.A. et al. (2000) Nature 404:411.
Gu, Z. et al. (1998) Genes Dev. 12:844.
Chen, Y. et al. (2004) Dev. Biol. 268:280.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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