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Osteoclast Differentiation Pathway Bioinformatics

Disease and disorder research has been conducted in relation to the Osteoclast Differentiation Pathway and Osteoporosis, Osteopenia, Arthritis, Bone Diseases, Rheumatoid Arthritis. The study of the Osteoclast Differentiation Pathway has been mentioned in research publications which can be found using our bioinformatics tool below. The Osteoclast Differentiation Pathway has been researched in relation to Bone Resorption, Bone Remodeling, Osteoblast Differentiation, Pathogenesis, Secretion. The Osteoclast Differentiation Pathway complements our catalog of research reagents including antibodies and ELISA kits against TNFSF11, TNFRSF11A, TNFRSF11B, BTF3P11, TNF.

Top Research Reagents

We have 2734 products for the study of the Osteoclast Differentiation Pathway that can be applied to Chromatin Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

Cathepsin K Antibody (2F1)

H00001513-M01

Western Blot: Cathepsin K Antibody (2F1) [H00001513-M01] - Analysis of CTSK expression in transfected 293T cell line by CTSK monoclonal antibody (M01), clone 2F1.Lane 1: CTSK transfected lysate(37 KDa).Lane 2: Non-transfected lysate.

Immunocytochemistry/Immunofluorescence: Cathepsin K Antibody (2F1) [H00001513-M01] - HeLa cell.

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

1 Publication

TRAF-2 Antibody

NB100-56173

Western Blot: TRAF-2 Antibody [NB100-56173] - Analysis of TRAF-2 in normal human tissues using this antibody. TRAF-2 is observed at ~60-64 kDa. Additional bands of lower molecular weight were seen in some cases, and may represent TRAF-2 degradation fragments.

Immunocytochemistry/Immunofluorescence: TRAF-2 Antibody [NB100-56173] - Immunostaining of HN30 and MCF-12a cells for TRAF2 3 days post-transfectionMCF-12a NT (DAPI): non-treated MCF-12a DAPI stained, MCF-12a NT (TRAF2-FITC): non-treated MCF-12a FITC stained for TRAF2, MCF-12a pNSP 5a3a (DAPI): MCF-12a transfected with pcDNA 3.0 NSP 5a3a DAPI stained, MCF-12a pNSP 5a3a (TRAF2-FITC): MCF-12a transfected with pcDNA 3.0 NSP 5a3a FITC stained for Traf-2, HN30 NT (DAPI): non-treated HN30 DAPI stained, HN30 NT (TRAF2-FITC): non-treated HN30 FITC stained for TRAF2, HN30 pNSP 5a3a (DAPI): HN30 transfected with pcDNA 3.0 NSP 5a3a DAPI stained, HN30 pNSP 5a3a (TRAF2-FITC): HN30 transfected with pcDNA 3.0 NSP 5a3a FITC stained for TRAF2. White arrows indicate apoptotic bodies. Image collected and cropped by Citeab from the following publication (A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma. Oncotarget (2011) licensed under a CC-BY license.

Rabbit Polyclonal
Species Human
Applications WB, Flow, ICC/IF

3 Publications

TRACP/PAP/ACP5 Antibody

H00000054-D01P

Western Blot: ACP5 Antibody [H00000054-D01P] - Analysis of ACP5 expression in human liver.

Western Blot: ACP5 Antibody [H00000054-D01P] - Analysis of ACP5 expression in transfected 293T cell line by ACP5 polyclonal antibody.Lane 1: ACP5 transfected lysate(36.60 KDa).Lane 2: Non-transfected lysate.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-P

3 Publications

IL-6 [HRP]

D6050B

N/A IL-6 [HRP]

N/A IL-6 [HRP]

Species Human

757 Publications

NFATC1/NFAT2 Antibody

NB100-56732

Western Blot: NFATC1/NFAT2 Antibody [NB100-56732] - Immortalized mouse podocytes. Image from verified customer review.

Immunocytochemistry/Immunofluorescence: NFATC1/NFAT2 Antibody [NB100-56732] - NFAT2 antibody was tested in Raw 246.7 cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and DyLight 550 (red). Image objective 40x. An antibody dilution of 1:10 was used.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Simple Western, ICC/IF

2 Reviews

4 Publications

NFkB p105/p50 Antibody (2J10D7) - BSA Free

NB100-56583

Western Blot: NFkB p105/p50 Antibody (2J10D7) [NB100-56583] - Analysis of p50 in HeLa lysate in the A) absence and B) presence of immunizing peptide using p50 antibody at 5 ug/ml.

Immunohistochemistry-Paraffin: NFkB p105/p50 Antibody (2J10D7) [NB100-56583] - IHC-P of rabbit aorta using NB100-56583. Secondary antibody: anti-mouse histofine ( Nisherei Bioscience Inc. ref: 414131F). Development: DAB (Dako ref: K346811-2) and counterstained with Hematoxylin. Submitted via verified customer review

Mouse Monoclonal
Species Human, Rat, Rabbit
Applications WB, Flow, IHC

1 Review

5 Publications

SCYL1 Antibody (2E5)

H00057410-M02

Western Blot: SCYL1 Antibody (2E5) [H00057410-M02] - SCYL1 monoclonal antibody (M02), clone 2E5. Analysis of SCYL1 expression in NIH/3T3.

Western Blot: SCYL1 Antibody (2E5) [H00057410-M02] - SCYL1 monoclonal antibody (M02), clone 2E5. Analysis of SCYL1 expression in PC-12.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, S-ELISA

1 Publication

TDRD7 Antibody

NBP1-87315

Immunohistochemistry: TDRD7 Antibody [NBP1-87315] - Staining of human testis shows cytoplasmic and nuclear positivity in subsets of testicular cells.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

1 Publication

TRAF-6 Inhibitor Peptide Set

NBP2-26506

TRAF6 Inhibitor Peptide Set [NBP2-26506] - The TRAF6 inhibitory peptide inhibits osteoclast ifferentiation: RAW264.7 cells were plated on 24-well plates and stimulated with RANKL and M-CSF and incubated in the presence of different concentrations of control peptide (PTD) or the TRAF6. The TRAF6 at the concentration above 30 uM suppressed osteoclast differentiation.

Species Human, Mouse, Rat
Applications In vitro, B/N

18 Publications

ERK2 Antibody [Unconjugated]

AF1230

Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, MCF-7 human breast cancer cell line, U937 human histiocytic lymphoma cell line, PC-12 rat adrenal pheochromocytoma cell line, and NIH-3T3 mouse embryonic fibroblast cell line. PVDF membrane was probed with 0.1 µg/mL of Rabbit Anti-Human/Mouse/Rat ERK2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1230) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # <a class=

ERK2 was detected in immersion fixed paraffin-embedded sections of human breast using Rabbit Anti-Human/Mouse/Rat ERK2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1230) at 3&nbsp;µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rabbit IgG VisUCyte&#8482; HRP Polymer Antibody (Catalog&nbsp;# <a class=

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, KO

3 Publications

Osteoprotegerin/TNFRSF11B [Biotin]

DY805

N/A Osteoprotegerin/TNFRSF11B [Biotin]

Species Human
Applications ELISA

86 Publications

CD40 Ligand/TNFSF5 [HRP]

DCDL40

N/A CD40 Ligand/TNFSF5 [HRP]

N/A CD40 Ligand/TNFSF5 [HRP]

Species Human
Applications ELISA

44 Publications

TNF-alpha [Unconjugated]

210-TA

Recombinant Human TNF-alpha (Catalog # 210-TA) has a molecular weight (MW) of 53.1 kDa as analyzed by SEC-MALS, suggesting that this protein is a homotrimer. MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).

Recombinant Human TNF-alpha (Catalog # 210‑TA) induces cytotoxicity in the L-929 mouse fibroblast cell line in the presence of the metabolic inhibitor actinomycin D. The ED<sub>50</sub> for this effect is 25‑100 pg/mL.

Species Human
Applications BA

3 Reviews

803 Publications

TRANCE/TNFSF11/RANK L

462-TR

<P align=left>Recombinant Mouse TRANCE/TNFSF11/RANK L (Catalog&nbsp;# 462-TR) induces osteoclast differentiation of&nbsp;the RAW&nbsp;264.7 mouse monocyte/macrophage cell line. The ED<SUB>50</SUB> for this effect is 5‑15&nbsp;ng/mL in the presence of 2.5&nbsp;μg/mL of a cross-linking antibody, Mouse Anti-polyHistidine Monoclonal Antibody (Catalog&nbsp;# <A class=NoLineLink href=

1&nbsp;μg/lane of Recombinant Mouse TRANCE/TNFSF11/RANK L was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at&nbsp;36 kDa.

Species Mouse
Applications BA

87 Publications

c-jun [p Ser63] Antibody (1018Y) [Unconjugated]

MAB8930

Western blot shows lysates of HEK293T human embryonic kidney cell line untreated (-) or treated (+) with 20 mJ/cm<sup>2</sup>ultraviolet light (UV) with a 30 minute recovery. PVDF membrane was probed with 0.5 µg/mL of Rabbit Anti-Human Phospho-c-Jun (S63) Monoclonal Antibody (Catalog # MAB8930) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # <a class=

c-Jun phosphorylated at S63 was detected in immersion fixed HeLa human cervical epithelial carcinoma cell line treated with Anisomycin using Rabbit Anti-Human Phospho-c-Jun (S63) Monoclonal Antibody (Catalog # MAB8930) at 1 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights&#8482; 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # <a class=

Rabbit Monoclonal
Species Human
Applications WB, Simple Western, ICC

1 Review

3 Publications

c-Fos Antibody (2H2)

NBP2-50037

Western Blot: c-Fos Antibody (2H2) [NBP2-50037] - Top panel: Analysis of c-Fos expression in HeLa cells using NBP2-50037. Lane 1: HeLa cells were serum-starved for 36 hours. Lane 2: Serum-starved HeLa cells were stimulated with 20% FBS (fetal bovine serum) for 2 hours. NBP2-50037 recognizes bands in the range of 50-65 kDa, which represent multiple forms of c-Fos. Serum starvation attenuates c-Fos expression, while 20% FBS strongly stimulates c-Fos expression. Bottom panel: Blot was stripped and probed with monoclonal antibody against GAPDH (NB300-221) used as loading control.

Immunocytochemistry/Immunofluorescence: c-Fos Antibody (2H2) [NBP2-50037] - Section of rat hippocampus stained with mouse monoclonal antibody to c-FOS NBP2-50037 in red and counterstained with rabbit polyclonal antibody to FOX3/NeuN. DAPI reveals nuclei of neurons and glia in blue. The hippocampal neurons stain green for FOX3/NeuN and a few also are expressing c-FOS, and so appear orange. These cells were spontaneously active at the time the animal was sacrificed.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

1 Review

18 Publications

RANK/TNFRSF11A Antibody (9A725) - BSA Free

NB100-56508

Western Blot: RANK/TNFRSF11A Antibody (9A725) [NB100-56508] - Analysis of RANK in transfected 293 cells using RANK antibody at 2 ug/ml.

Flow Cytometry: RANK/TNFRSF11A Antibody (9A725) - BSA Free [NB100-56508] - An intracellular stain was performed on Raw264.7 cells with RANK/TNFRSF11A Antibody (9A725) NB100-56508 (blue) and a matched isotype control MAB002 (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature, followed by Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Dylight 550 (84540, Thermo Fisher).

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, IHC

18 Publications

Related Genes

The Osteoclast Differentiation Pathway has been researched against:

Related Pathways

The Osteoclast Differentiation Pathway has been linked to:

Related Diseases

The Osteoclast Differentiation Pathway has been studied in relation to diseases such as:

Related PTMs

The Osteoclast Differentiation Pathway has been studied in relation to posttranslational modifications (PTMs) including:

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