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Epigenetics

Epigenetics of Depression: How Can Psychological Stress Alter Your DNA?

Breast cancer stem cells survive chemotherapy through S100A10-ANXA2-SPT6 interaction that epigenetically promotes OCT4-mediated stemness

Chromatin reader domains of DNMT-targeting protein, UHRF1, are responsible for cancerous DNA hypermethylation

Negative feedback regulation of EPAS1 gene in non-small cell lung cancer through DNA methyltransferases

Nickel induces migratory and invasive phenotype in human epithelial cells by epigenetically activating ZEB1

Epigenetic Control of Autophagy

Bad news for stomach cancer: BAMBI protein inhibits gastric carcinoma via TGF-beta/epithelial-mesenchymal transition signaling

Autophagy: Pro or Anti-tumorigenic? And the role of epigenetics in this debate

By Christina Towers, PhD

Article Review: Glucose-induced transcriptional regulation in cancer

Epigenetic mechanisms have been implicated in many physiological and pathophysiological processes. Among these, histone modifications including methylation, phosphorylation, acetylation and ubiquitination, significantly modify gene expression.

Epigenetic mechanisms: new insights on the regulation of autophagy

Autophagy more than a cytosolic event

Autophagy is a cellular process whereby cytosolic components are broken down and eliminated or recycled. As a homeostatic mechanism, basal autophagic activity eliminates excess or abnormal proteins and organelles1. As an induced process, autophagy may be triggered by various external challenges, such as decreased nutrient and energy resources, and oxidative stress1.

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