Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ELISA, IHC, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
XPF/ERCC4 is suggested to play a role in the repair of DNA double-strand breaks (DSB), homologous recombination, and gene conversion via single-strand annealing (SSA). XPF/ERCC4 is an endonuclease that incises 5-prime DNA. Defects in XPF/ERCC4 cause xeroderma pigmentosum VI (XP6) an autosomal recessive disease characterized by hypersensitivity to sunlight and a predisposition to skin cancer as well as neurological abnormalities. Defects in XPF/ERCC4 are also responsible for XFE progeroid syndrome, a syndrome characterized by dwarfism, cachexia, and microcephaly.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
2072 |
| Alternate Names |
- DNA excision repair protein ERCC-4
- DNA repair protein complementing XP-F cells
- EC 3.1
- ERCC11
- excision repair cross-complementing rodent repair deficiency, complementationgroup 4
- xeroderma pigmentosum, complementation group F
- XPFcomplementing defective, in Chinese hamster
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Related XPF Blog Posts
Check out the latest blog posts on XPF.
NER Antibodies in Cancer Research
We at Novus Biologicals have over 230 products in our antibody catalog devoted to nucleotide excision repair. NER is a multi-stage sequential process involving over 30 proteins, all of which have been widely studied. Being the primary method to repair... Read more.
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