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ZNF148 Antibody [Janelia Fluor® 646]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Janelia Fluor 646

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ZNF148 Antibody [Janelia Fluor® 646] Summary

Immunogen
The immunogen for this product maps to a region between residue 744 and 794 of human Zinc Finger DNA-Binding Protein 89 using the numbering given in entry NP_068799.2 (GeneID 7707).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ZNF148
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for ZNF148 Antibody [Janelia Fluor® 646]

  • BERF-1
  • BFCOL1
  • CACCC box-binding protein
  • CLL-associated antigen KW-10
  • HT-BETA
  • pHZ-52
  • Transcription factor ZBP-89
  • ZBP89
  • ZBP-89
  • ZFP148zinc finger protein 148 (pHZ-52)
  • Zinc finger DNA-binding protein 89
  • zinc finger protein 148

Background

ZBP-89, also known as BFCOL1, BERF1 and ZNF 148, is a zinc finger transcription factor that is universally expressed. ZBP-89, a Kruppel-like repressor protein, is the silencer element binding factor for Vimentin. ZBP-89 has been shown to bind to GC-rich DNA elements in promoters for gastrin, ornithine decarboxylase and the cyclin-dependent kinase inhibitor p21 (also designated Cip1 or WAF1). ZBP-89 expression is induced by trans-retinoic acid or butyrate, which also induces terminal differentiation of colon cancer cells. ZBP-89 cooperates with histone acetyltransferase coactivator p300 in the regulation of p21, a cyclin-dependent kinase inhibitor whose associated gene is a target gene of p53. ZBP-89 also regulates cell proliferation, in part, through its ability to directly bind the p53 protein and retard its nuclear export. Elevated levels of ZBP-89 induce growth arrest and apoptosis in human gastrointestinal cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ZNF148