ZNF148 Products

Description

ZBP-89, also known as BFCOL1, BERF1 and ZNF 148, is a zinc finger transcription factor that is universally expressed. ZBP-89, a Kruppel-like repressor protein, is the silencer element binding factor for Vimentin. ZBP-89 has been shown to bind to GC-rich DNA elements in promoters for gastrin, ornithine decarboxylase and the cyclin-dependent kinase inhibitor p21 (also designated Cip1 or WAF1). ZBP-89 expression is induced by trans-retinoic acid or butyrate, which also induces terminal differentiation of colon cancer cells. ZBP-89 cooperates with histone acetyltransferase coactivator p300 in the regulation of p21, a cyclin-dependent kinase inhibitor whose associated gene is a target gene of p53. ZBP-89 also regulates cell proliferation, in part, through its ability to directly bind the p53 protein and retard its nuclear export. Elevated levels of ZBP-89 induce growth arrest and apoptosis in human gastrointestinal cells.

Bioinformatics

Entrez	22661 Mouse 58820 Rat 7707 Human
Uniprot	NM_021964 Human NP_068799 Human NP_068799.2 Human Q9UQR1 Human
Product By Gene ID	7707
Alternate Names	BERF-1 BFCOL1 CACCC box-binding protein CLL-associated antigen KW-10 HT-BETA pHZ-52 Transcription factor ZBP-89 ZBP89 ZBP-89 ZFP148zinc finger protein 148 (pHZ-52) Zinc finger DNA-binding protein 89 zinc finger protein 148