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VEGFR2/KDR/Flk-1 Antibody [FITC]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, Flow, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
FITC

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB100-530AF350
Alexa Fluor 405
NB100-530AF405
Alexa Fluor 488
NB100-530AF488
Alexa Fluor 532
NB100-530AF532
Alexa Fluor 594
NB100-530AF594
Alexa Fluor 647
NB100-530AF647
Alexa Fluor 700
NB100-530AF700
Alexa Fluor 750
NB100-530AF750
Allophycocyanin
NB100-530APC
Biotin
NB100-530B
CoraFluor 1
NB100-530CL1
DyLight 350
NB100-530UV
DyLight 405
NB100-530V
DyLight 488
NB100-530G
DyLight 550
NB100-530R
DyLight 594
NB100-530DL594
DyLight 650
NB100-530C
DyLight 680
NB100-530FR
DyLight 755
NB100-530IR
HRP
NB100-530H
Janelia Fluor 525
NB100-530JF525
Janelia Fluor 549
NB100-530JF549
Janelia Fluor 585
NB100-530JF585
Janelia Fluor 635
NB100-530JF635
Janelia Fluor 646
NB100-530JF646
Janelia Fluor 669
NB100-530JF669
PE
NB100-530PE
PerCP
NB100-530PCP
Unconjugated
NB100-530
mFluor Violet 450 SE
NB100-530MFV450
mFluor Violet 500 SE
NB100-530MFV500
mFluor Violet 610 SE
NB100-530MFV610
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VEGFR2/KDR/Flk-1 Antibody [FITC] Summary

Immunogen
A synthetic peptide made to a C-terminal region of the mouse VEGF Receptor 2 protein (between residues 1300-1367). [Swiss-Prot# P35918]
Localization
Type 1 membrane protein
Marker
Endothelial Cell Marker
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KDR
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Publications
Read Publication using NB100-530F.

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 28183816).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for VEGFR2/KDR/Flk-1 Antibody [FITC]

  • CD309 antigen
  • CD309
  • EC 2.7.10
  • EC 2.7.10.1
  • Fetal liver kinase 1
  • fetal liver kinase-1
  • Flk1
  • Flk-1
  • FLK1tyrosine kinase growth factor receptor
  • KDR
  • kinase insert domain receptor (a type III receptor tyrosine kinase)
  • Kinase insert domain receptor
  • KRD1
  • Ly73
  • Protein-tyrosine kinase receptor flk-1
  • soluble VEGFR2
  • vascular endothelial growth factor receptor 2
  • VEGF R2
  • VEGFR
  • VEGFR2
  • VEGFR-2

Background

VEGFs such as VEGFA, VEGFC, VEGFD etc. activate RTKs namely VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), and VEGFR-3 (Flt-4), that regulates angiogenic as well as lymphangiogenic transduction signals. VEGF Receptor 2 (VEGFR2) is the most prominent cell-surface receptor for VEGF ligands and binding of VEGFs to isoform 1 leads to multiple signaling cascades activation. PLCG1 activation results in production of signaling molecules (diacylglycerol, inositol 1,4,5-trisphosphate etc) and PKC activation. VEGFR2 is involved in the activation of MAPK1/ERK2, MAPK3/ERK1, and MAPK as well as AKT signaling pathways. It facilitates phosphorylation of PIK3R1 (regulatory subunit of PI3K), cytoskeletal actin reorganization and PTK2/FAK1 activation. VEGFR2 is essential for VEGFA-mediated induction of NOS2/NOS3, leading to the production of NO by endothelial cells and is involved in phosphorylation of FYN, NCK1, NOS3, PIK3R1 and SRC. Isoforms -2 and -3 function as decoy receptors for VEGFs, and isoform -2 plays as negative regulator of VEGFA/VEGFC-mediated lymphangiogenesis by limiting free VEGFA and/or VEGFC levels alongwith preventing their binding to VEGFR3. Versatile signaling effects by VEGFR2 leads to its regulatory role in processes such as angiogenesis, vascular development, vascular permeability, embryonic hematopoiesis, and promotes proliferation, survival, migration and differentiation of endothelial cells alongwith facilitating reorganization of the actin cytoskeleton.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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VEGFR2/KDR/Flk-1
Antibody [FITC]
NB100-530F
VEGFR2/KDR/Flk-1 Antibody [FITC]
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC

Publications for VEGFR2/KDR/Flk-1 Antibody (NB100-530F)(1)


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Secondary Antibodies

 

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Bioinformatics

Gene Symbol KDR