UGT1A3 Antibody (1C10)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 application: WB.

Showing Publications 1 - 4 of 4.

Publications using H00054659-M02	Applications	Species
Steffen L, Sandra K, Stefan P et al. A Gilbert Syndrome-Associated Haplotype Protects Against Fatty Liver Disease in Humanized Transgenic Mice. Sci Rep. 2020-05-26 [PMID: 32457304]
Wang Y, Liu S, Dong W et al. Combination of hesperetin and platinum enhances anticancer effect on lung adenocarcinoma. Biomed Pharmacother. 2019-03-16 [PMID: 30889488]
Ehmer U, Kalthoff S, Fakundiny B et al. Gilbert syndrome redefined: a complex genetic haplotype influences the regulation of glucuronidation. Hepatology. 2012-06-01 [PMID: 22213127] (WB)	WB
Kalthoff S, Ehmer U, Freiberg N et al. Coffee induces expression of glucuronosyltransferases via the aryl hydrocarbon receptor and Nrf2 in liver and stomach. Gastroenterology. 2010-06-20 [PMID: 20600030]

Array H00054659-M02

• UGT1A3 Antibody
• UGT1A3 Lysate