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Tsukushi/TSK Antibody (462310)

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB
Clone
462310
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB6376-SP
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Tsukushi/TSK Antibody (462310) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Tsukushi/TSK
Thr18-Leu354
Accession # Q8CBR6
Specificity
Detects mouse Tsukushi/TSK in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 25% cross-reactivity with recombinant human Tsukushi/TSK is observed.
Source
N/A
Isotype
IgG2c
Clonality
Monoclonal
Host
Rat
Gene
TSKU
Purity Statement
Protein A or G purified from hybridoma culture supernatant
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Sterile PBS to a final concentration of 0.5 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Tsukushi/TSK Antibody (462310)

  • E2IG4
  • E2IG4E2-induced gene 4 protein
  • leucine rich repeat containing 54
  • Leucine-rich repeat-containing protein 54
  • LRRC54
  • TSK
  • TSKtsukushi homolog
  • TSKU
  • tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)
  • Tsukushi
  • tsukushi, small leucine rich proteoglycan
  • tsukushin

Background

TSK, also known as Tsukushi and Leucine-rich repeat-containing protein 54, is a member of the small leucine-rich proteoglycan (SLRP) family of extracellular matrix proteins, which are characterized by leucine-rich repeats (LRR) flanked by conserved cysteines. Mouse TSK is a secreted glycoprotein that has a predicted molecular weight of 36.5 kDa and contains 9 LLR. Proteoglycan modification of TSK has not been shown. Estrogen treatment in breast cancer cell lines upregulates TSK, and so TSK is proposed to be involved in hormonally regulated extracellular matrix remodeling. Mouse TSK shares 96%, 85%, 51%, and 49% sequence identity with rat, human, chicken, and Xenopus TSK, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol TSKU
Uniprot