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TRAILR1/TNFRSF10A Antibody (DR-4-02) [PE/Cy5.5]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
DR-4-02
Clonality
Monoclonal
Host
Mouse
Conjugate
PE/Cy5.5

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-31343AF350
Alexa Fluor 405
NBP2-31343AF405
Alexa Fluor 488
NBP2-31343AF488
Alexa Fluor 532
NBP2-31343AF532
Alexa Fluor 594
NBP2-31343AF594
Alexa Fluor 647
NBP2-31343AF647
Alexa Fluor 700
NBP2-31343AF700
Alexa Fluor 750
NBP2-31343AF750
Allophycocyanin
NBP2-31343APC
Allophycocyanin/Cy7
NBP2-31343APCCY7
Biotin
NBP2-31343B
CoraFluor 1
NBP2-31343CL1
DyLight 350
NBP2-31343UV
DyLight 405
NBP2-31343V
DyLight 488
NBP2-31343G
DyLight 550
NBP2-31343R
DyLight 594
NBP2-31343DL594
DyLight 650
NBP2-31343C
DyLight 680
NBP2-31343FR
DyLight 755
NBP2-31343IR
FITC
NBP2-31343F
Janelia Fluor 525
NBP2-31343JF525
Janelia Fluor 549
NBP2-31343JF549
Janelia Fluor 646
NBP2-31343JF646
Janelia Fluor 669
NBP2-31343JF669
PE
NBP2-31343PE
PE/Atto594
NBP2-31343PEATT594
PE/Cy7
NBP2-31343PECY7
PerCP
NBP2-31343PCP
Unconjugated
NBP2-31343
mFluor Violet 450 SE
NBP2-31343MFV450
mFluor Violet 500 SE
NBP2-31343MFV500
mFluor Violet 610 SE
NBP2-31343MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-31343
Azide and BSA Free
NBP2-31343
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TRAILR1/TNFRSF10A Antibody (DR-4-02) [PE/Cy5.5] Summary

Additional Information
Clone DR-4-02 was used by HLDA to establish CD designation.
Immunogen
Fusion protein (Human). Fusion protein containing the extracellular part of DR4 and the constant part of the heavy chain of the human IgG1 (NM_003844.3).
Localization
Cell Membrane
Specificity
The mouse monoclonal antibody DR-4-02 recognizes an extracellular epitope of TRAIL-R1 (DR4), a human death receptor 4 expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TNFRSF10A
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined. For optimal results using our Tandem dyes, please avoid prolonged exposure to light or extreme temperature fluctuations. These can lead to irreversible degradation or decoupling. When staining intracellular targets, specific attention to the fixation and permeabilization steps in your flow protocol may be required. Please contact our technical support team at technical@novusbio.com if you have any questions.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Alternate Names for TRAILR1/TNFRSF10A Antibody (DR-4-02) [PE/Cy5.5]

  • APO2
  • CD261 antigen
  • CD261
  • cytotoxic TRAIL receptor
  • Death receptor 4
  • DR4 TRAIL receptor 1
  • DR4
  • TNF-related apoptosis inducing ligand receptor 1
  • TNF-related apoptosis-inducing ligand receptor 1
  • TNFRSF10A
  • TRAIL R1
  • TRAILR1
  • TRAIL-R1
  • TRAILR-1
  • TRAILR1MGC9365
  • tumor necrosis factor receptor superfamily member 10A
  • tumor necrosis factor receptor superfamily, member 10a

Background

TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol TNFRSF10A