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TLE1 Antibody (TLE1/8007R) [DyLight 405]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
TLE1/8007R
Clonality
Monoclonal
Host
Rabbit
Conjugate
DyLight 405

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-20696AF350
Alexa Fluor 405
NBP3-20696AF405
Alexa Fluor 488
NBP3-20696AF488
Alexa Fluor 532
NBP3-20696AF532
Alexa Fluor 594
NBP3-20696AF594
Alexa Fluor 647
NBP3-20696AF647
Alexa Fluor 700
NBP3-20696AF700
Alexa Fluor 750
NBP3-20696AF750
Allophycocyanin
NBP3-20696APC
Biotin
NBP3-20696B
CoraFluor 1
NBP3-20696CL1
DyLight 350
NBP3-20696UV
DyLight 488
NBP3-20696G
DyLight 550
NBP3-20696R
DyLight 594
NBP3-20696DL594
DyLight 650
NBP3-20696C
DyLight 680
NBP3-20696FR
DyLight 755
NBP3-20696IR
FITC
NBP3-20696F
HRP
NBP3-20696H
Janelia Fluor 525
NBP3-20696JF525
Janelia Fluor 549
NBP3-20696JF549
Janelia Fluor 646
NBP3-20696JF646
Janelia Fluor 669
NBP3-20696JF669
PE
NBP3-20696PE
PerCP
NBP3-20696PCP
Unconjugated
NBP3-20606-100ug
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP3-20606-100ug
Azide and BSA Free
NBP3-20696
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TLE1 Antibody (TLE1/8007R) [DyLight 405] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
Recombinant human TLE1 fragment (aa 175-338) (exact sequence is proprietary)
Localization
Nucleus.
Specificity
Key players in the Notch pathway are the TLE genes, which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. Transducin-like enhancer protein 1 (TLE1) is a protein that is encoded by the TLE1 gene and is involved in control of hematopoiesis, neuronal, and terminal epithelial differentiation. Positive immunohistochemical nuclear staining with anti-TLE-1 has been shown to be a useful addition to an IHC panel when differentiating synovial sarcoma from other soft tissue malignancies.
Isotype
IgG Kappa
Clonality
Monoclonal
Host
Rabbit
Gene
TLE1
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for TLE1 Antibody (TLE1/8007R) [DyLight 405]

  • E(Sp1) homolog
  • enhancer of split groucho 1
  • ESG
  • ESG1Enhancer of split groucho-like protein 1
  • GRG1
  • TLE1
  • transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
  • transducin-like enhancer of split 1, homolog of Drosophila E(sp1)
  • transducin-like enhancer protein 1

Background

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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TLE1 Antibody
(TLE1/8007R) [DyLight ...
NBP3-20696V
TLE1 Antibody (TLE1/8007R) [DyLight 405]
Species: Hu
Applications: IHC

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Bioinformatics

Gene Symbol TLE1