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TIMP-2 Antibody (TIMP2/2488R) [Janelia Fluor® 525]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, Gp, Rb, ZeSpecies Glossary
Applications IHC
Clone
TIMP2/2488R
Clonality
Monoclonal
Host
Rabbit
Conjugate
Janelia Fluor 525

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-08721AF350
Alexa Fluor 405
NBP3-08721AF405
Alexa Fluor 488
NBP3-08721AF488
Alexa Fluor 532
NBP3-08721AF532
Alexa Fluor 594
NBP3-08721AF594
Alexa Fluor 647
NBP3-08721AF647
Alexa Fluor 700
NBP3-08721AF700
Alexa Fluor 750
NBP3-08721AF750
Allophycocyanin
NBP3-08721APC
Biotin
NBP3-08721B
CoraFluor 1
NBP3-08721CL1
DyLight 350
NBP3-08721UV
DyLight 405
NBP3-08721V
DyLight 488
NBP3-08721G
DyLight 550
NBP3-08721R
DyLight 594
NBP3-08721DL594
DyLight 650
NBP3-08721C
DyLight 680
NBP3-08721FR
DyLight 755
NBP3-08721IR
FITC
NBP3-08721F
HRP
NBP3-08721H
Janelia Fluor 549
NBP3-08721JF549
Janelia Fluor 585
NBP3-08721JF585
Janelia Fluor 635
NBP3-08721JF635
Janelia Fluor 646
NBP3-08721JF646
Janelia Fluor 669
NBP3-08721JF669
PE
NBP3-08721PE
PerCP
NBP3-08721PCP
Unconjugated
NBP3-07724-100ug
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP3-07724-100ug
Azide and BSA Free
NBP3-08721
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TIMP-2 Antibody (TIMP2/2488R) [Janelia Fluor® 525] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
A synthetic peptide from the N-terminus of human TIMP-2 protein (aa56-66) (DSGNDIYGNPI) (Uniprot: P16035)
Localization
Cytoplasm and Cell Surface
Specificity
It recognizes a protein of 21kDa, identified as tissue inhibitor of metalloproteinases-2 (TIMP-2). It is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
TIMP2
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for TIMP-2 Antibody (TIMP2/2488R) [Janelia Fluor® 525]

  • CSC-21Ktissue inhibitor of metalloproteinase 2
  • metalloproteinase inhibitor 2
  • TIMP metallopeptidase inhibitor 2
  • TIMP2
  • TIMP-2
  • Tissue inhibitor of metalloproteinases 2

Background

The TIMP2 gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role a

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TIMP2