Reactivity | Hu, Mu, Rt, Bv, Gp, Rb, ZeSpecies Glossary |
Applications | IHC |
Clone | TIMP2/2488R |
Clonality | Monoclonal |
Host | Rabbit |
Conjugate | Alexa Fluor 488 |
Additional Information | Recombinant Monoclonal Antibody |
Immunogen | A synthetic peptide from the N-terminus of human TIMP-2 protein (aa56-66) (DSGNDIYGNPI) (Uniprot: P16035) |
Localization | Cytoplasm and Cell Surface |
Specificity | It recognizes a protein of 21kDa, identified as tissue inhibitor of metalloproteinases-2 (TIMP-2). It is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. |
Isotype | IgG |
Clonality | Monoclonal |
Host | Rabbit |
Gene | TIMP2 |
Purity | Protein A or G purified |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Application Notes | Optimal dilution of this antibody should be experimentally determined. |
Storage | Store at 4C in the dark. |
Buffer | 50mM Sodium Borate |
Preservative | 0.05% Sodium Azide |
Purity | Protein A or G purified |
Secondary Antibodies |
Isotype Controls |
Research Areas for TIMP-2 Antibody (NBP3-08721AF488)Find related products by research area.
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Suppressing breast cancer metastasis: The role of hypoxia-induced RhoB expression and activation By Jamshed Arslan, Pharm. D., PhD. The Ras homologous (Rho) GTPase family of signaling molecules has over 20 members, which typically cycle between active (GTP-bound) and inactive (GDP-bound) states. These small GTPa... Read full blog post. |
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Gene Symbol | TIMP2 |