| Reactivity | MuSpecies Glossary |
| Applications | IHC |
| Clone | 739206 |
| Clonality | Monoclonal |
| Host | Rat |
| Conjugate | Unconjugated |
| Concentration | LYOPH |
| Immunogen | E. coli-derived recombinant mouse TDRD1 Asn831-Lys960 Accession # Q99MV1 |
| Specificity | Detects mouse TDRD1 in direct ELISAs. In direct ELISAs, 100% cross-reactivity with
recombinant human TDRD1 is observed. |
| Source | N/A |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Host | Rat |
| Gene | TDRD1 |
| Purity Statement | Protein A or G purified from hybridoma culture supernatant |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Dilutions |
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| Publications |
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| Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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| Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
| Preservative | No Preservative |
| Concentration | LYOPH |
| Reconstitution Instructions | Sterile PBS to a final concentration of 0.5 mg/mL. |
TDRD1 (Tudor domain containing protein 1; also MTR-1) is a 130-145 kDa member of the Tudor family of proteins. It is expressed in spermatocytes and spermatids, and forms part of an RNA-silencing complex that regulates gene expression. TDRD1, through its Tudor and MYND domains, binds methylated PIWI (P-element-induced wimpy testis) protein and PIWI-interacting RNA loading factor, respectively. This serves to promote the recruitment of germline-specific small RNAs into a PIWI ribonucleoprotein complex. Mouse TDRD1 is 1172 aa in length. It contains one MYND-type Zn finger region (aa 163-199), and four methyl-binding Tudor domains (aa 307-1032). Over aa 831-960, mouse TDRD1 shares 96% and 66% aa identity with rat and human TDRD1, respectively.
| Publication using MAB6296 | Applications | Species |
|---|---|---|
| RP Yadav, JA Mäkelä, H Hyssälä, S Cisneros-M, N Kotaja DICER regulates the expression of major satellite repeat transcripts and meiotic chromosome segregation during spermatogenesis Nucleic Acids Res., 2020-07-27;0(0):. 2020-07-27 [PMID: 32484548] (Flow Cytometry, ICC, Mouse) | Flow Cytometry, ICC | Mouse |
Secondary Antibodies |
Isotype Controls |
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