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TCR alpha/beta Antibody (Desire-1) - Azide and BSA Free

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, ICC/IF, IP
Clone
Desire-1
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Format
Azide and BSA Free
Concentration
1 mg/ml

Order Details

  • Size / Catalog#QtyPrice
    NBP3-09020-0.025mg
    0.025 mg
    $219.00
    12-14 Business Days
    NBP3-09020-0.2mg
    0.2 mg
    $469.00
    12-14 Business Days
    View Available Formulations
    Catalog# & Formulation Size Price
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TCR alpha/beta Antibody (Desire-1) - Azide and BSA Free Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
mAb desire-1 was obtained after fusion of spleen cells from a BALB.K mouse immunised twice with KB5-C20 clone cells in RPMI 1640 medium, with non-Ig-producing myeloma cells X63-Ag8.653. Desire-1 was selected for its capacity to inhibit selectively the H-2Kb-specific cytolysis by clone KB5-C20.
Specificity
mAb desire-1 recognises an epitope contributed by both the alpha and beta chains of the KB5-C20 TCR.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TRA
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunoprecipitation
Application Notes
This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

Desire-1 has been used for the immunoprecipitation of soluble TCR molecules (Gregoire 1991 & Hua 1986). An FITC conjugated desire-1 has been used in flow cytometric analysis as a marker for clonotype expression (Schonrich 1991). Further, a Fab fragment derived from desire-1 has been used in the crystallisation of the T-cell receptor for 3D structure determination (Housset 1997).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Proclin 300
Concentration
1 mg/ml
Purity
Protein A purified

Alternate Names for TCR alpha/beta Antibody (Desire-1) - Azide and BSA Free

  • C)
  • D
  • FLJ22602
  • J
  • MGC117436
  • MGC22624
  • MGC23964
  • MGC71411
  • T cell receptor alpha locus
  • T-cell antigen receptor, alpha polypeptide
  • T-cell receptor, alpha (V
  • TCRA
  • TCRD
  • TRA

Background

The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol TRA