TACE/ADAM17 Antibody (111633) [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TACE is a member of the ADAM family that contains A Disintegrin And Metalloprotease-like domain. Like other membrane-anchored ADAMs, TACE consists of a pro domain with a cysteine switch and furin cleavage sequence, a catalytic domain with the zinc-binding site and Met-turn expected for reprolysins, a disintegrin-like domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and the cytoplasmic domain. In addition to its ability to release the 17 kDa extracellular form of Tumor Necrosis Factor-alpha (TNF-alpha ) from the 26 kDa membrane-anchored TNF-alpha , TACE also plays an essential role in shedding ectodomains from a variety of proteins such as L-Selectin, Transforming Growth Factor-alpha , Amyloid Protein Precursor, and Notch-1 receptor. TACE mRNA is present in virtually every tissue and TACE protein resides both on the cell surface and in the cell.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using FAB9301P	Applications	Species
Gerrit Hugendieck, Marcus Lettau, Svenja Andreas, Sabrina Neumann, Natalie Reinhardt, Philipp Arnold et al. Chemotherapy‐induced release of ADAM17 bearing EV as a potential resistance mechanism in ovarian cancer Journal of Extracellular Vesicles 2023-07-05 [PMID: 37408115]
T Tyrinova, O Leplina, S Mishinov, M Tikhonova, E Dolgova, A Proskurina, V Stupack, S Bogachev, A Ostanin, E Chernykh Defective Regulation of Membrane TNF&alpha Expression in Dendritic Cells of Glioblastoma Patients Leads to the Impairment of Cytotoxic Activity against Autologous Tumor Cells Int J Mol Sci, 2020-04-21;21(8):. 2020-04-21 [PMID: 32326230] (Flow Cytometry, Human)	Flow Cytometry	Human
Z Parackova, P Vrabcova, I Zentsova, J Kayserova, I Richtrova, L Sojka, K Stechova, Z Sumnik, A Sediva Enhanced STAT3 phosphorylation and PD-L1 expression in myeloid dendritic cells indicate impaired IL-27Ralpha signaling in type 1 diabetes Sci Rep, 2020-01-16;10(1):493. 2020-01-16 [PMID: 31949260] (Flow Cytometry, Human)	Flow Cytometry	Human
S Dreschers, C Platen, A Ludwig, C Gille, N Köstlin, TW Orlikowsky Metalloproteinases TACE and MMP-9 Differentially Regulate Death Factors on Adult and Neonatal Monocytes After Infection with Escherichia coli Int J Mol Sci, 2019-03-20;20(6):. 2019-03-20 [PMID: 30897723] (Flow Cytometry, Human)	Flow Cytometry	Human
Nina Hedemann, Christoph Rogmans, Susanne Sebens, Daniela Wesch, Manuel Reichert, Dirk Schmidt-Arras et al. ADAM17 inhibition enhances platinum efficiency in ovarian cancer Oncotarget 2018-03-23 [PMID: 29662625]
H Lécuyer, Z Virion, JP Barnier, S Matczak, S Bourdoulou, E Bianchini, F Saller, D Borgel, X Nassif, M Coureuil An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans PLoS Pathog., 2018-04-09;14(4):e1006981. 2018-04-09 [PMID: 29630665] (Flow Cytometry, Human)	Flow Cytometry	Human
Neekun Sharma, Camille V. Trinidad, Andrew P. Trembath, Mary A. Markiewicz NKG2D signaling between human NK cells enhances TACE-mediated TNF-alpha release1 The Journal of Immunology 2017-10-15 [PMID: 28893955]
Guranda Chitadze, Marcus Lettau, Stefanie Luecke, Ting Wang, Ottmar Janssen, Daniel Fürst et al. NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human gamma δ T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors OncoImmunology 2016-04-02 [PMID: 27141377]
Moreira-Tabaka H, Peluso J, Vonesch JL, Hentsch D, Kessler P, Reimund JM, Dumont S, Muller CD Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE. PLoS ONE, 2012-03-30;7(3):e34184. 2012-03-30 [PMID: 22479555] (Flow Cytometry, Human)	Flow Cytometry	Human
Wang CH, Huang CD, Lin HC, Huang TT, Lee KY, Lo YL, Lin SM, Chung KF, Kuo HP Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway. J. Allergy Clin. Immunol., 2012-02-09;129(5):1367-76. 2012-02-09 [PMID: 22325070] (Flow Cytometry, Human)	Flow Cytometry	Human
Canault M, Leroyer AS, Peiretti F, Leseche G, Tedgui A, Bonardo B, Alessi MC, Boulanger CM, Nalbone G Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1. Am. J. Pathol., 2007-09-14;171(5):1713-23. 2007-09-14 [PMID: 17872973] (Flow Cytometry, Human)	Flow Cytometry	Human
Canault M, Tellier E, Bonardo B, Mas E, Aumailley M, Juhan-Vague I, Nalbone G, Peiretti F FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity. J. Cell. Physiol., 2006-08-01;208(2):363-72. 2006-08-01 [PMID: 16619241] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 12 Publications. Collapse Publications.

Array FAB9301P

• TACE/ADAM17 Antibodies
• TACE/ADAM17 ELISA Kits
• TACE/ADAM17 Proteins
• TACE/ADAM17 ELISA
• TACE/ADAM17 Proteins and Enzymes