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TACE/ADAM17 Antibody (111633) [DyLight 488]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, IP, CyTOF-ready, KO
Clone
111633
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 488

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB9301U-100UG
Alexa Fluor 405
FAB9301V-100UG
Alexa Fluor 488
FAB9301G-100UG
Alexa Fluor 532
FAB9301X
Alexa Fluor 594
FAB9301T-100UG
Alexa Fluor 647
FAB9301R-100UG
Alexa Fluor 700
FAB9301N-100UG
Alexa Fluor 750
FAB9301S-100UG
Allophycocyanin
FAB9301A
Allophycocyanin/Cy7
FAB9301APCCY7
Biotin
FAB9301B
CoraFluor 1
FAB9301CL1
DyLight 350
FAB9301D
DyLight 405
FAB9301E
DyLight 550
FAB9301L
DyLight 594
FAB9301M
DyLight 650
FAB9301W
DyLight 680
FAB9301Y
DyLight 755
FAB9301Z
HRP
FAB9301H
Janelia Fluor 525
FAB9301JF525
Janelia Fluor 549
FAB9301I
Janelia Fluor 585
FAB9301JF585
Janelia Fluor 635
FAB9301JF635
Janelia Fluor 646
FAB9301J
Janelia Fluor 669
FAB9301JF669
PE/Atto594
FAB9301PEATT594
PE/Cy5.5
FAB9301PECY55
PE/Cy7
FAB9301PECY7
PerCP
FAB9301C
Phycoerythrin
FAB9301P
Unconjugated
MAB9301-100
mFluor Violet 450 SE
FAB9301MFV450
mFluor Violet 500 SE
FAB9301MFV500
mFluor Violet 610 SE
FAB9301MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB9301-100
Carrier Free
FAB9301P
Carrier Free
MAB9301-SP
Carrier Free
MAB9301-500
Carrier Free
MAB9301-100
Carrier Free
FAB9301V-100UG
Carrier Free
FAB9301U-100UG
Carrier Free
FAB9301T-100UG
Carrier Free
FAB9301S-100UG
Carrier Free
FAB9301R-100UG
Carrier Free
FAB9301N-100UG
Carrier Free
FAB9301G-100UG
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TACE/ADAM17 Antibody (111633) [DyLight 488] Summary

Immunogen
Insect ovarian cell line T. ni-derived recombinant human TACE/ADAM17
Pro18-Asn671
Accession # P78536
Specificity
Detects the ectodomain of human TACE/ADAM17 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with the ectodomain of recombinant human ADAM8, 9, 15 and recombinant mouse ADAM10 is observed.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ADAM17
Purity
Protein A or G purified from ascites
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunoprecipitation
  • Knockout Validated
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from ascites

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for TACE/ADAM17 Antibody (111633) [DyLight 488]

  • ADAM 17
  • ADAM metallopeptidase domain 17
  • ADAM metallopeptidase domain 18
  • ADAM17
  • ADAM18
  • CD156b antigen
  • CD156b
  • CSVP
  • disintegrin and metalloproteinase domain-containing protein 17
  • EC 3.4.24.86
  • MGC71942
  • Snake venom-like protease
  • TACE
  • TACEcSVP
  • TNF-alpha convertase
  • TNF-alpha converting enzyme
  • TNF-alpha-converting enzyme
  • tumor necrosis factor, alpha, converting enzyme

Background

ADAM17 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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TACE/ADAM17
Antibody (111633) [Dy ...
FAB9301K
TACE/ADAM17 Antibody (111633) [DyLight 488]
Species: Hu
Applications: WB, Flow, IP, CyTOF-ready, KO

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Bioinformatics

Gene Symbol ADAM17