Can I use this antibody with species other than those listed?

Name: Survivin Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF886
Rating: 4.5 (2 reviews)

The species we have listed are validated and therefore have a 100% guarantee to work with this antibody. We cannot guarantee that this will work with other species.

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Survivin Antibody [Unconjugated]

(99 Publications)

(2 Reviews)

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Western blot shows lysates of MCF-7 human breast cancer cell line and Jurkat human acute T cell leukemia cell line. PVDF membrane was probed with 0.5 µg/mL of Rabbit Anti-Human Survivin Antigen Affinity-purified ...read more

Survivin was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using Rabbit Anti-Human Survivin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF886) at 3 µg/mL for 1 ...read more

Survivin was detected in immersion fixed paraffin-embedded sections of human prostate cancer tissue using 10 µg/mL Rabbit Anti-Human Survivin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF886) overnight at ...read more

Simple Western lane view shows lysates of Jurkat human acute T cell leukemia cell line and MCF‑7 human breast cancer cell line, loaded at 0.2 mg/mL. A specific band was detected for Survivin at approximately 23 kDa ...read more

Survivin expression in human chondrosarcoma. Immunohistochemistry and immunoblot for survivin (red staining) from human chondrosarcoma specimens. A: Low-power image of human high-grade chondrosarcoma displays strong ...read more

Survivin is required for the proliferation of trophoblastic cells and depletion induces a G2/M arrest.(A) Cell viability assay. JAR (left panel), BeWo (middle panel) and HTR-8/SVneo (HTR, right panel) cells were ...read more

Genetic Strategies: ATM and DNA-PKCS induce cell cycle arrest after Survivin-RNAi. a: Western blot analysis of HCT116 and HCT116shATM total cell lysates following Survivin-RNAi (shSurv). Included are ...read more

Survivin in tubulointerstitial cells.A, Western blot analysis of survivin protein in the renal cortex of wild type and Itga8-/- mice after induction of unilateral ureter obstruction (UUO). B,Exemplary photomicrographs ...read more

Inhibition of PI3K gamma attenuates tumor growth in xenograft models associated with infiltrated macrophages.a Experimental procedure illustrating the TG100-115 treatment regimen in BALB/c mice. b CT26 cells (5 × 105 ...read more

Opposite effects of M1 and M2 macrophages on tumor growth.a Tumor images and b tumor growth 3 weeks after transplantation of HCT116 cells after long-term coculture with differentiated M0, M1, or M2 macrophages (see ...read more

Role of PI3K gamma in TAM-mediated colon cancer cell viability and EMT characteristics.mRNA expression levels of genes involved in the proinflammatory response (IL-1 alpha , IL-1 beta , CXCL10, and IL-8) and ...read more

Analysis for RNA-induced silencing complex cleavage products in treated tumors and immunoblot analysis for target protein complexes and death signals in primary tumors. (A) Total RNA was isolated from tumor tissue and ...read more

Ex vivo analysis of the role of macrophage CM in colon cancer patient-derived cells (PDCs).a Estimation of PDC viability after coculture with macrophage CM for 24 h using the WST-1 assay. Error bars are derived from ...read more

Response over time to TBG-RNAi-CK2 treatment in PC3-LN4 xenograft tumors(A) Verification of nuclear and cytosol protein fractionation from tumor tissue is shown by comparative immunoblot analysis of CK2 alpha alpha ...read more

Immunoblot analyses following small interfering RNA-mediated downregulation of CDK11 and CK2 in breast cancer cells. Immunoblot analysis of MDA-MB-231 and SUM-149 cell lysates following small interfering RNA (siRNA) ...read more

Product Details

Summary

Reactivity	HuSpecies Glossary
Applications	WB, Simple Western, IHC
Clonality	Polyclonal
Host	Rabbit
Conjugate	Unconjugated
Concentration	LYOPH

Validated by:

Genetic Strategies

Order Details

View Available Formulations

Catalog# & Formulation	Size	Price
Carrier Free AF886-SP

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Survivin Antibody [Unconjugated] Summary

Immunogen	E. coli-derived recombinant human Survivin aa 1-142
Specificity	Detects human Survivin. This antibody also detects an unidentified ~51 kDa protein band.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Rabbit
Gene	BIRC5
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Applications/Dilutions

Dilutions

Immunohistochemistry 3-15 ug/mL
Simple Western 5 ug/mL
Western Blot 0.5 ug/mL

Application Notes

In Simple Western only 10-15 uL of the recommended dilution is used per data point.

Reviewed Applications

Read 2 Reviews rated 4.5

using
AF886 in the following applications:

Immunocytochemistry

Publications

Read Publications using
AF886 in the following applications:

Affinity Chromatography
1 publication
Flow Cytometry
1 publication
ICC
4 publications
IHC
4 publications
IHC-P
1 publication
Immunohistochemistry
1 publication
Immunoprecipitation
1 publication
Western Blot
47 publications

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Survivin Antibody [Unconjugated]

API4
apoptosis inhibitor 4
Apoptosis inhibitor survivin
baculoviral IAP repeat-containing 5
Baculoviral IAP Repeat-Containing Protein 5
BIRC5
EPR-1
IAP4
survivin variant 3 alpha
Survivin

Background

Survivin also known as Apoptosis inhibitor survivin and Baculoviral IAP repeat-containing protein 5 (BIRC5) is an 18 kDa member of the inhibitor of apoptosis (IAP) gene family, which encodes negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple Baculovirus IAP repeat (BIR) domains, but this gene encodes seven isoforms with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Survivin is expressed in a cell cycle-dependent manner and associates with the mitotic apparatus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Survivin Antibody
[Unconjugated]

AF886

Species: Hu

Applications: WB, Simple Western, IHC

Publications for Survivin Antibody (AF886)(99)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 8 applications: Affinity Chromatography, Flow Cytometry, ICC, IHC, IHC-P, Immunohistochemistry, Immunoprecipitation, Western Blot.

Showing Publications 1 - 10 of 99. Show All 99 Publications.

Publications using AF886	Applications	Species
Q B Alenzi, F; Survivin: A key apoptosis inhibitor in COVID-19 infection and its implication for treatment protocol Saudi journal of biological sciences 2024-07-01 [PMID: 38831893] (Immunohistochemistry, Human)	Immunohistochemistry	Human
Lin, IL;Lin, YT;Chang, YC;Kondapuram, SK;Lin, KH;Chen, PC;Kuo, CY;Coumar, MS;Cheung, CHA; The SMAC mimetic GDC-0152 is a direct ABCB1-ATPase activity modulator and BIRC5 expression suppressor in cancer cells Toxicology and applied pharmacology 2024-03-05 [PMID: 38452945] (Western Blot, Human)	Western Blot	Human
A Delgado, R Griera, N Llor, E López-Agui, MA Busquets, V Noé, CJ Ciudad Trioleyl Pyridinium, a Cationic Transfection Agent for the Lipofection of Therapeutic Oligonucleotides into Mammalian Cells Pharmaceutics, 2023-01-27;15(2):. 2023-01-27 [PMID: 36839742] (Western Blot, Human)	Western Blot	Human
N Carrasco, M Garrido, I Montenegro, A Madrid, R Hartley, I González, M Rubilar, J Villena, M Valenzuela Antitumoral Activity of Leptocarpha rivularis Flower Extracts against Gastric Cancer Cells International Journal of Molecular Sciences, 2023-01-11;24(2):. 2023-01-11 [PMID: 36674960] (Western Blot, Human)	Western Blot	Human
SM Woo, S Kim, SU Seo, S Kim, JW Park, G Kim, YR Choi, K Hur, TK Kwon Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5 Cell Death & Disease, 2022-09-24;13(9):821. 2022-09-24 [PMID: 36153316] (Immunoprecipitation, Human)	Immunoprecipitation	Human
David Danielpour, Sarah Corum, Patrick Leahy, Anusha Bangalore Jagged-1 is induced by mTOR inhibitors in renal cancer cells through an Akt/ALK5/Smad4-dependent mechanism Current Research in Pharmacology and Drug Discovery 7/4/2022 [PMID: 35992379]
Yung-Chieh Chang, Min-Chieh Shieh, Yen-Hsuan Chang, Wei-Lun Huang, Wu-Chou Su, Fong-Yu Cheng et al. Development of a cancer cells self‑activating and miR‑125a‑5p expressing poly‑pharmacological nanodrug for cancer treatment International Journal of Molecular Medicine 6/14/2022 [PMID: 35703361]
S Mohammadho, LC Ho, L Fang, J Xu, F Medina-Bol Arachidin-1, a Prenylated Stilbenoid from Peanut, Induces Apoptosis in Triple-Negative Breast Cancer Cells International Journal of Molecular Sciences, 2022-01-20;23(3):. 2022-01-20 [PMID: 35163062] (Western Blot, Human)	Western Blot	Human
David Danielpour, Sarah Corum, Scott M. Welford, Eswar Shankar Hypoxia represses early responses of prostate and renal cancer cells to YM155 independent of HIF-1 alpha and HIF-2 alpha Current Research in Pharmacology and Drug Discovery 1/1/2022 [PMID: 35005610]
E Aubets, M Chillon, CJ Ciudad, V Noé PolyPurine Reverse Hoogsteen Hairpins Work as RNA Species for Gene Silencing International Journal of Molecular Sciences, 2021-09-16;22(18):. 2021-09-16 [PMID: 34576188] (Western Blot, Human)	Western Blot	Human
Sarah Adel Hakim, Hoda Hassan Abou Gabal Diagnostic Utility of BAP1, EZH2 and Survivin in Differentiating Pleural Epithelioid Mesothelioma and Reactive Mesothelial Hyperplasia: Immunohistochemical Study Pathology and Oncology Research 4/9/2021 [PMID: 34257556]
W Jugel, A Aigner, S Michen, A Hagstotz, A Ewe, D Appelhans, G Schackert, A Temme, S Tietze Targeted RNAi of BIRC5/Survivin Using Antibody-Conjugated Poly(Propylene Imine)-Based Polyplexes Inhibits Growth of PSCA-Positive Tumors Pharmaceutics, 2021-05-08;13(5):. 2021-05-08 [PMID: 34066833] (Western Blot, Human)	Western Blot	Human
Yu Ren, Xue Wang, Shuaishuai Huang, Yangkai Xu, Guobin Weng, Rui Yu Alternol Sensitizes Renal Carcinoma Cells to TRAIL-Induced Apoptosis Frontiers in Pharmacology 3/25/2021 [PMID: 33841136]
Ö Güllülü, S Hehlgans, BE Mayer, I Gö beta ner, C Petraki, M Hoffmann, MJ Dombrowsky, P Kunzmann, K Hamacher, K Strebhardt, E Fokas, C Rödel, C Münch, F Rödel A spatial and functional interaction of a heterotetramer Survivin-DNA-PKcs complex in DNA damage response Cancer Research, 2021-01-06;0(0):. 2021-01-06 [PMID: 33408118] (Western Blot, Human)	Western Blot	Human
AJ Rodrigues, JJ Bandolik, FK Hansen, T Kurz, A Hamacher, MU Kassack Priming with HDAC Inhibitors Sensitizes Ovarian Cancer Cells to Treatment with Cisplatin and HSP90 Inhibitors Int J Mol Sci, 2020-11-05;21(21):. 2020-11-05 [PMID: 33167494] (Western Blot, Human)	Western Blot	Human
Maritza P. Garrido, Renato Salvatierra, Manuel Valenzuela-Valderrama, Christopher Vallejos, Nicole Bruneau, Andrea Hernández et al. Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells Pharmaceuticals (Basel) 10/16/2020 [PMID: 33081077]
KS Schweitzer, N Jinawath, R Yonescu, K Ni, N Rush, V Charoensaw, I Bronova, E Berdyshev, SM Leach, LA Gillenwate, RP Bowler, DB Pearse, CA Griffin, I Petrache IGSF3 mutation identified in patient with severe COPD alters cell function and motility JCI Insight, 2020-07-23;0(0):. 2020-07-23 [PMID: 32573489] (Western Blot, Human)	Western Blot	Human
YS Lee, SJ Song, HK Hong, BY Oh, WY Lee, YB Cho The FBW7-MCL-1 axis is key in M1 and M2 macrophage-related colon cancer cell progression: validating the immunotherapeutic value of targeting PI3Kgamma Exp. Mol. Med., 2020-05-22;52(5):815-831. 2020-05-22 [PMID: 32444799] (Western Blot, Human, Mouse)	Western Blot	Human, Mouse
F Nishisaka, K Taniguchi, M Tsugane, G Hirata, A Takagi, N Asakawa, A Kurita, H Takahashi, N Ogo, Y Shishido, A Asai Antitumor activity of a novel oral signal transducer and activator of transcription 3 inhibitor YHO-1701 Cancer Sci., 2020-03-24;111(5):1774-1784. 2020-03-24 [PMID: 32112605] (Western Blot, Human)	Western Blot	Human
MP Garrido, I Hurtado, M Valenzuela, R Salvatierr, A Hernández, M Vega, A Selman, AFG Quest, C Romero NGF-Enhanced Vasculogenic Properties of Epithelial Ovarian Cancer Cells Is Reduced by Inhibition of the COX-2/PGE2 Signaling Axis Cancers (Basel), 2019-12-07;11(12):. 2019-12-07 [PMID: 31817839] (IHC, Western Blot, Human)	IHC, Western Blot	Human
TY Lin, HH Chan, SH Chen, S Sarvagalla, PS Chen, MS Coumar, SM Cheng, YC Chang, CH Lin, E Leung, CHA Cheung BIRC5/Survivin is a novel ATG12-ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells Autophagy, 2019-10-15;0(0):1-18. 2019-10-15 [PMID: 31612776] (IHC, Western Blot, Human)	IHC, Western Blot	Human
Claus Weinholdt, Henri Wichmann, Johanna Kotrba, David H. Ardell, Matthias Kappler, Alexander W. Eckert et al. Prediction of regulatory targets of alternative isoforms of the epidermal growth factor receptor in a glioblastoma cell line BMC Bioinformatics 12/1/2019 [PMID: 31438847]
David Danielpour, Zhaofeng Gao, Patrick M. Zmina, Eswar Shankar, Benjamin C. Shultes, Raul Jobava et al. Early Cellular Responses of Prostate Carcinoma Cells to Sepantronium Bromide (YM155) Involve Suppression of mTORC1 by AMPK Scientific Reports 8/8/2019 [PMID: 31395901]
Kyoung Bun Lee, Kyu Sang Lee, Hye Seung Lee Tumor-Associated Protein Profiles in Kaposi Sarcoma and Mimicking Vascular Tumors, and Their Pathological Implications International Journal of Molecular Sciences 6/27/2019 [PMID: 31252633]
C Fitzpatric, MF Bendek, M Briones, N Farfán, VA Silva, G Nardocci, M Montecino, A Boland, JF Deleuze, J Villegas, C Villota, V Silva, L Lobos-Gonz, V Borgna, E Barrey, LO Burzio, VA Burzio Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors Cell Death Dis, 2019-05-29;10(6):423. 2019-05-29 [PMID: 31142736] (Western Blot, Human)	Western Blot	Human
SL Tsai, YC Chang, S Sarvagalla, S Wang, MS Coumar, CHA Cheung Cloning, expression, and purification of the recombinant pro-apoptotic dominant-negative survivin T34A-C84A protein in Escherichia coli Protein Expr. Purif., 2019-04-17;160(0):73-83. 2019-04-17 [PMID: 31004782] (Western Blot, Human)	Western Blot	Human
Rehana L. Ahmed, Daniel P. Shaughnessy, Todd P. Knutson, Rachel I. Vogel, Khalil Ahmed, Betsy T. Kren et al. CDK11 Loss Induces Cell Cycle Dysfunction and Death of BRAF and NRAS Melanoma Cells Pharmaceuticals (Basel) 4/2/2019 [PMID: 30987032]
Linder B, Wehle A, Hehlgans S et al. Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling Cancers (Basel) 3/12/2019 [PMID: 30871073]
André Wirries, Samir Jabari, Esther P. Jansen, Silvia Roth, Elizabeth Figueroa-Juárez, Thaddeus T. Wissniowski et al. Panobinostat mediated cell death: a novel therapeutic approach for osteosarcoma Oncotarget 8/31/2018 [PMID: 30250645]
S Hehlgans, P Booms, Ö Güllülü, R Sader, C Rödel, P Balermpas, F Rödel, S Ghanaati Radiation Sensitization of Basal Cell and Head and Neck Squamous Cell Carcinoma by the Hedgehog Pathway Inhibitor Vismodegib Int J Mol Sci, 2018-08-23;19(9):. 2018-08-23 [PMID: 30142876] (Western Blot, Human)	Western Blot	Human
Hisako Ono, Yoshihiro Sowa, Mano Horinaka, Yosuke Iizumi, Motoki Watanabe, Mie Morita et al. The histone deacetylase inhibitor OBP-801 and eribulin synergistically inhibit the growth of triple-negative breast cancer cells with the suppression of survivin, Bcl-xL, and the MAPK pathway Breast Cancer Research and Treatment 8/1/2018 [PMID: 29752686]
Kei Kushitani, Vishwa Jeet Amatya, Amany Sayed Mawas, Rui Suzuki, Yoshihiro Miyata, Morihito Okada et al. Utility of Survivin, BAP1, and Ki‑67 immunohistochemistry in distinguishing epithelioid mesothelioma from reactive mesothelial hyperplasia Oncology Letters 1/10/2018 [PMID: 29467873]
X Jiang, PY Mak, H Mu, D Mak, S Kornblau, Q Zhang, P Ruvolo, JK Burks, W Zhang, T McQueen, R Pan, H Zhou, M Konopleva, JE Cortes, Q Liu, M Andreeff, BZ Carter, W Tao Disruption of Wnt/?-catenin exerts anti-leukemia activity and synergizes with FLT3 inhibition in FLT3-mutant acute myeloid leukemia Clin. Cancer Res., 2018-02-20;0(0):. 2018-02-20 [PMID: 29463558] (Western Blot, Human)	Western Blot	Human
Adriï¿½n Ramï¿½rez De Arellano, Annie Riera Leal, Edgar I Lopez-Pulido, Luis Renee Gonzï¿½lez-Lucano, Josï¿½ Macï¿½as Barragan, Susana Del Toro Arreola et al. A 60 kDa prolactin variant secreted by cervical cancer cells modulates apoptosis and cytokine production Oncology Reports 1/19/2018 [PMID: 29399697]
M Conde, S Michen, R Wiedemuth, B Klink, E Schröck, G Schackert, A Temme Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells BMC Cancer, 2017-12-28;17(1):889. 2017-12-28 [PMID: 29282022] (Western Blot, Human)	Western Blot	Human
T Takamura, M Horinaka, S Yasuda, S Toriyama, Y Aono, Y Sowa, T Miki, O Ukimura, T Sakai FGFR inhibitor BGJ398 and HDAC inhibitor OBP-801 synergistically inhibit cell growth and induce apoptosis in bladder cancer cells Oncol. Rep., 2017-12-01;39(2):627-632. 12/1/2017 [PMID: 29207153]
TI Oh, YM Lee, TJ Nam, YS Ko, S Mah, J Kim, Y Kim, RH Reddy, YJ Kim, S Hong, JH Lim Fascaplysin Exerts Anti-Cancer Effects through the Downregulation of Survivin and HIF-1? and Inhibition of VEGFR2 and TRKA Int J Mol Sci, 2017-09-29;18(10):. 9/29/2017 [PMID: 28961193]
Sanne Hindriksen, Arne J. Bramer, My Anh Truong, Martijn J. M. Vromans, Jasmin B. Post, Ingrid Verlaan-Klink et al. Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells PLOS ONE 6/22/2017 [PMID: 28640891]
H Zhou, P Y Mak, H Mu, D H Mak, Z Zeng, J Cortes et al. Combined inhibition of beta -catenin and Bcr–Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo Leukemia 10/1/2017 [PMID: 28321124]
TR Reich, OJ Switzeny, M Renovanz, C Sommer, B Kaina, M Christmann, MT Tomicic Epigenetic silencing of XAF1 in high-grade gliomas is associated with IDH1 status and improved clinical outcome Oncotarget, 2017-02-28;0(0):. 2017-02-28 [PMID: 28122345] (Western Blot, Human)	Western Blot	Human
Ahmed K, Kren BT, Abedin MJ et al. CK2 targeted RNAi therapeutic delivered via malignant cell-directed tenfibgen nanocapsule: dose and molecular mechanisms of response in xenograft prostate tumors. Oncotarget. 9/20/2016 [PMID: 27557516]
Seon Min Woo, Kyoung-jin Min, Bo Ram Seo, Taeg Kyu Kwon YM155 sensitizes TRAIL-induced apoptosis through cathepsin S-dependent down-regulation of Mcl-1 and NF-kappa B-mediated down-regulation of c-FLIP expression in human renal carcinoma Caki cells Oncotarget 9/20/2016 [PMID: 27528031]
Pro-Apoptotic Activity of New Honokiol/Triphenylmethane Analogues in B-Cell Lymphoid Malignancies Molecules, 2016-07-30;21(8):. 2016-07-30 [PMID: 27483232] (Flow Cytometry, Human)	Flow Cytometry	Human
Katharina Engel USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B-cell lymphoma EMBO Mol Med, 2016-08-01;0(0):. 2016-08-01 [PMID: 27317434] (Western Blot, Human)	Western Blot	Human
Delivery of a survivin promoter-driven antisense survivin-expressing plasmid DNA as a cancer therapeutic: a proof-of-concept study Onco Targets Ther, 2016-05-03;9(0):2601-13. 2016-05-03 [PMID: 27217778] (Western Blot, Human)	Western Blot	Human
Jane Murphy, William W. Hall, Lee Ratner, Noreen Sheehy Novel interactions between the HTLV antisense proteins HBZ and APH-2 and the NFAR protein family: Implications for the HTLV lifecycles Virology 7/1/2016 [PMID: 27110706]
Jane Ying-Chieh Lee, Ching-Wen Kuo, Shing-Ling Tsai, Siao Muk Cheng, Shang-Hung Chen, Hsiu-Han Chan et al. Inhibition of HDAC3- and HDAC6-Promoted Survivin Expression Plays an Important Role in SAHA-Induced Autophagy and Viability Reduction in Breast Cancer Cells Frontiers in Pharmacology 3/31/2016 [PMID: 27065869]
Cristina Florean, Michael Schnekenburger, Jin-Young Lee, Kyung Rok Kim, Aloran Mazumder, Sungmi Song et al. Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells Oncotarget 4/26/2016 [PMID: 27006469]
Tayyaba Afsar, Janeen H. Trembley, Christine E. Salomon, Suhail Razak, Muhammad Rashid Khan, Khalil Ahmed Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways Scientific Reports 3/15/2016 [PMID: 26975752]
Ines Marek, Till Lichtneger, Nada Cordasic, Karl F. Hilgers, Gudrun Volkert, Fabian Fahlbusch et al. Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover PLOS ONE 3/3/2016 [PMID: 26938996]
Li X, Pathi S, Safe S Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors. BMC Cancer, 2015-12-16;15(0):974. 2015-12-16 [PMID: 26673922] (Western Blot, Human)	Western Blot	Human
Matthias Bache, Christin Münch, Antje Güttler, Henri Wichmann, Katharina Theuerkorn, Daniel Emmerich et al. Betulinyl Sulfamates as Anticancer Agents and Radiosensitizers in Human Breast Cancer Cells International Journal of Molecular Sciences 11/3/2015 [PMID: 26540049]
Hehlgans S, Oppermann J, Reichert S et al. The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis. Radiat Oncol 9/19/2015 [PMID: 26383618]
Ramirez de Arellano A, Lopez-Pulido E, Martinez-Neri P, Estrada Chavez C, Gonzalez Lucano R, Fafutis-Morris M, Aguilar-Lemarroy A, Munoz-Valle J, Pereira-Suarez A STAT3 activation is required for the antiapoptotic effects of prolactin in cervical cancer cells. Cancer Cell Int, 2015-09-04;15(0):83. 2015-09-04 [PMID: 26346346] (Western Blot, Human)	Western Blot	Human
Ingrid A M van Roosmalen, Carlos R Reis, Rita Setroikromo, Saravanan Yuvaraj, Justin V Joseph, Pieter G Tepper et al. The ER stress inducer DMC enhances TRAIL-induced apoptosis in glioblastoma SpringerPlus 12/1/2014 [PMID: 26331107]
Betsy T Kren, Gretchen M Unger, Md J Abedin, Rachel I Vogel, Christine M Henzler, Khalil Ahmed et al. Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy Breast Cancer Research 12/1/2015 [PMID: 25837326]
Giuseppina Salzano, Gemma Navarro, Malav S. Trivedi, Giuseppe De Rosa, Vladimir P. Torchilin Multifunctional Polymeric Micelles Co-loaded with Anti–Survivin siRNA and Paclitaxel Overcome Drug Resistance in an Animal Model of Ovarian Cancer Molecular Cancer Therapeutics 4/1/2015 [PMID: 25657335]
Matthias Bache, Stephan Bernhardt, Sarina Passin, Henri Wichmann, Anja Hein, Martin P Zschornak et al. Betulinic acid derivatives NVX-207 and B10 for treatment of glioblastoma--an in vitro study of cytotoxicity and radiosensitization International Journal of Molecular Sciences 10/30/2014 [PMID: 25361208]
Fernandez J, Rodriguez D, Valenzuela M, Calderon C, Urzua U, Munroe D, Rosas C, Lemus D, Diaz N, Wright M, Leyton L, Tapia J, Quest A Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced beta-catenin/Tcf-Lef dependent transcription. Mol Cancer, 2014-09-09;13(0):209. 2014-09-09 [PMID: 25204429] (Western Blot, Human)	Western Blot	Human
Nestal de Moraes G, Castro C, Salustiano E, Dumas M, Costas F, Lam E, Costa P, Maia R The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors. Int J Oncol, 2014-08-21;45(5):1949-58. 2014-08-21 [PMID: 25174716] (Western Blot, Human)	Western Blot	Human
Qin Q, Cheng H, Lu J, Zhan L, Zheng J, Cai J, Yang X, Xu L, Zhu H, Zhang C, Liu J, Ma J, Zhang X, Dai S, Sun X Small-molecule survivin inhibitor YM155 enhances radiosensitization in esophageal squamous cell carcinoma by the abrogation of G2 checkpoint and suppression of homologous recombination repair. J Hematol Oncol, 2014-08-20;7(0):62. 2014-08-20 [PMID: 25139395] (Western Blot, Human)	Western Blot	Human
Umemori Y, Kuribayashi K, Nirasawa S, Kondoh T, Tanaka M, Kobayashi D, Watanabe N Protein kinase C zeta regulates survivin expression and inhibits apoptosis in colon cancer. Int J Oncol, 2014-06-10;45(3):1043-50. 2014-06-10 [PMID: 24920238] (Western Blot, Human)	Western Blot	Human
Wiedemuth R, Klink B, Topfer K, Schrock E, Schackert G, Tatsuka M, Temme A Survivin safeguards chromosome numbers and protects from aneuploidy independently from p53. Mol Cancer, 2014-05-09;13(0):107. 2014-05-09 [PMID: 24886358] (Western Blot, Human)	Western Blot	Human
Weber T, Meinhardt M, Zastrow S, Wienke A, Erdmann K, Hofmann J, Fuessel S, Wirth M Stage-dependent prognostic impact of molecular signatures in clear cell renal cell carcinoma. Onco Targets Ther, 2014-05-02;7(0):645-54. 2014-05-02 [PMID: 24833908] (IHC, Human)	IHC	Human
Gallouet A, Travert M, Bresson-Bepoldin L, Guilloton F, Pangault C, Caulet-Maugendre S, Lamy T, Tarte K, Guillaudeux T COX-2-independent effects of celecoxib sensitize lymphoma B cells to TRAIL-mediated apoptosis. Clin Cancer Res, 2014-03-17;20(10):2663-73. 2014-03-17 [PMID: 24637636] (Western Blot, Human)	Western Blot	Human
Ghosh S, Yigit M, Uchida M, Ross A, Barteneva N, Moore A, Medarova Z Sequence-dependent combination therapy with doxorubicin and a survivin-specific small interfering RNA nanodrug demonstrates efficacy in models of adenocarcinoma. Int J Cancer, 2013-10-15;134(7):1758-66. 2013-10-15 [PMID: 24114765] (Western Blot, Human)	Western Blot	Human
Gupta , Subash C, Francis , Sajin K, Nair , Mangalam, Mo , Yin-Yuan, Aggarwal , Bharat B Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway. J Biol Chem, 2013-09-27;288(45):32343-56. 2013-09-27 [PMID: 24078627] (Western Blot, Human)	Western Blot	Human
Yi Shu, Dan Shu, Farzin Haque, Peixuan Guo Fabrication of pRNA nanoparticles to deliver therapeutic RNAs and bioactive compounds into tumor cells Nature Protocols 9/1/2013 [PMID: 23928498]
Hage C, Rausch V, Giese N, Giese T, Schonsiegel F, Labsch S, Nwaeburu C, Mattern J, Gladkich J, Herr I The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer. Cell Death Dis, 2013-05-09;4(0):e627. 2013-05-09 [PMID: 23661005] (Western Blot, Human)	Western Blot	Human
Kyung Song, Eswar Shankar, Jiayi Yang, Kara L. Bane, Reema Wahdan-Alaswad, David Danielpour Critical Role of a Survivin/TGF-beta /mTORC1 Axis in IGF-I-Mediated Growth of Prostate Epithelial Cells PLoS ONE 5/1/2013 [PMID: 23658701]
Munoz-Repeto I, Garcia M, Kamieniak M, Ramon Y Cajal T, Domingo S, Cazorla A, Garcia Donas J, Hernando Polo S, Garcia Sagredo J, Hernandez E, Lacambra C, Saez R, Robles L, Borrego S, Prat J, Palacios J, Benitez J Phenotypic characterization of hereditary epithelial ovarian cancer based on a tissue microarray study. Histol Histopathol, 2013-01-01;28(1):133-44. 2013-01-01 [PMID: 23233066] (IHC-P, Human)	IHC-P	Human
Engesaeter B, Engebraaten O, Florenes V, Maelandsmo G Dacarbazine and the agonistic TRAIL receptor-2 antibody lexatumumab induce synergistic anticancer effects in melanoma. PLoS ONE, 2012-09-20;7(9):e45492. 2012-09-20 [PMID: 23029050] (Western Blot, Human)	Western Blot	Human
Ingeborg Fraunholz, Claus Rödel, Luitpold Distel, Marget Rave-Fränk, Daniela Kohler, Stefan Falk et al. High survivin expression as a risk factor in patients with anal carcinoma treated with concurrent chemoradiotherapy Radiation Oncology 12/1/2012 [PMID: 22697293]
Heather L. Watt, Zakaria Rachid, Bertrand J. Jean-Claude The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries Journal of Signal Transduction 3/7/2012 [PMID: 22523681]
Wagner L, Marschall V, Karl S, Cristofanon S, Zobel K, Deshayes K, Vucic D, Debatin K, Fulda S Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-kappaB-dependent manner. Oncogene, 2012-04-02;32(8):988-97. 2012-04-02 [PMID: 22469979] (Western Blot, Human)	Western Blot	Human
Loder S, Fakler M, Schoeneberger H, Cristofanon S, Leibacher J, Vanlangenakker N, Bertrand MJ, Vandenabeele P, Jeremias I, Debatin KM, Fulda S RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis. Leukemia, 2011-12-16;26(5):1020-9. 2011-12-16 [PMID: 22173242] (Western Blot, Human)	Western Blot	Human
Matthias Bache, Martin P Zschornak, Sarina Passin, Jacqueline Kessler, Henri Wichmann, Matthias Kappler et al. Increased betulinic acid induced cytotoxicity and radiosensitivity in glioma cells under hypoxic conditions Radiation Oncology 12/1/2011 [PMID: 21906280]
Lechler P, Balakrishnan S, Schaumburger J et al. The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro. BMC Musculoskelet Disord. 7/5/2011 [PMID: 21729321]
Toosi , Siavash, Habib , Nancy, Torres , Geneviev, Reynolds , Sandra R, Bystryn , Jean-Cla Serum levels of inhibitors of apoptotic proteins (IAPs) change with IVIg therapy in pemphigus. J Invest Dermatol, 2011-06-30;131(11):2327-9. 2011-06-30 [PMID: 21716321] (Western Blot, Human)	Western Blot	Human
Lechler P, Renkawitz T, Campean V et al. The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro. BMC Cancer11(1):120. 4/2/2011 [PMID: 21457573]
Anjaiah Srirangam, Monica Milani, Ranjana Mitra, Zhijun Guo, Mariangellys Rodriguez, Hitesh Kathuria et al. The Human Immunodeficiency Virus Protease Inhibitor Ritonavir Inhibits Lung Cancer Cells, in Part, by Inhibition of Survivin Journal of Thoracic Oncology 4/1/2011 [PMID: 21270666]
Won Jun Sohn, Jung Won Lee, Dong-Guk Park Change in Expression of Survivin Caused by Using Oxaliplatin in HCT116 Colon Cancer Cells Journal of the Korean Society of Coloproctology 8/31/2010 [PMID: 21152225]
Brooks AD, Jacobsen KM, Li W et al. Bortezomib sensitizes human renal cell carcinomas to TRAIL apoptosis through increased activation of caspase-8 in the death-inducing signaling complex. Mol Cancer Res. 5/1/2010 [PMID: 20442297]
Javier Rivera Guzman, Seiji Fukuda, Louis M. Pelus Inhibition of caspase-3 by Survivin prevents Wee1 Kinase degradation and promotes cell survival by maintaining phosphorylation of p34Cdc2 Gene Ther Mol Biol 1/11/2010 [PMID: 20428502]
Siegelin MD, Gaiser T, Habel A, Siegelin Y Myricetin sensitizes malignant glioma cells to TRAIL-mediated apoptosis by down-regulation of the short isoform of FLIP and bcl-2. Cancer Lett., 2009-04-26;283(2):230-8. 2009-04-26 [PMID: 19398149] (Western Blot, Human)	Western Blot	Human
Zhang Y, Huang S, Dong W, Li L, Feng Y, Pan L, Han Z, Wang X, Ren G, Su D, Huang B, Lu J SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells. Cancer Lett., 2008-12-23;277(1):29-37. 2008-12-23 [PMID: 19108950] (Western Blot, Human)	Western Blot	Human
Schile AJ, Garcia-Fernandez M, Steller H Regulation of apoptosis by XIAP ubiquitin-ligase activity. Genes Dev., 2008-08-15;22(16):2256-66. 2008-08-15 [PMID: 18708583] (Western Blot, Mouse)	Western Blot	Mouse
Hu CK, Coughlin M, Field CM, Mitchison TJ Cell polarization during monopolar cytokinesis. J. Cell Biol., 2008-04-14;181(2):195-202. 2008-04-14 [PMID: 18411311] (ICC, Human)	ICC	Human
Kojima K, Konopleva M, Samudio IJ Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells. Cancer Res., 2007-04-01;67(7):3210-9. 2007-04-01 [PMID: 17409429] (Western Blot, Human)	Western Blot	Human
Temme A, Rodriguez JA, Hendruschk S, Gunes S, Weigle B, Schakel K, Schmitz M, Bachmann M, Schackert G, Rieber EP Nuclear localization of Survivin renders HeLa tumor cells more sensitive to apoptosis by induction of p53 and Bax. Cancer Lett., 2006-11-07;250(2):177-93. 2006-11-07 [PMID: 17084966] (ICC, Human)	ICC	Human
Botchkareva NV, Kahn M, Ahluwalia G, Shander D Survivin in the human hair follicle. J. Invest. Dermatol., 2006-08-31;127(2):479-82. 2006-08-31 [PMID: 16946715] (IHC, Human)	IHC	Human
Perabo FG, Frossler C, Landwehrs G, Schmidt DH, von Rucker A, Wirger A, Muller SC Indirubin-3'-monoxime, a CDK inhibitor induces growth inhibition and apoptosis-independent up-regulation of survivin in transitional cell cancer. Anticancer Res., 2006-05-01;26(3):2129-35. 2006-05-01 [PMID: 16827155] (Western Blot, Human)	Western Blot	Human
Vassina EM, Yousefi S, Simon D, Zwicky C, Conus S, Simon HU cIAP-2 and survivin contribute to cytokine-mediated delayed eosinophil apoptosis. Eur. J. Immunol., 2006-07-01;36(7):1975-84. 2006-07-01 [PMID: 16761316] (Western Blot, Human)	Western Blot	Human
McNeish IA, Lopes R, Bell SJ, McKay TR, Fernandez M, Lockley M, Wheatley SP, Lemoine NR Survivin interacts with Smac/DIABLO in ovarian carcinoma cells but is redundant in Smac-mediated apoptosis. Exp. Cell Res., 2005-01-01;302(1):69-82. 2005-01-01 [PMID: 15541727] (Affinity Chromatography, Western Blot, Human)	Affinity Chromatography, Western Blot	Human
Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell, 2004-07-23;118(2):187-202. 2004-07-23 [PMID: 15260989] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Altznauer F, Martinelli S, Yousefi S, Thurig C, Schmid I, Conway EM, Schoni MH, Vogt P, Mueller C, Fey MF, Zangemeister-Wittke U, Simon HU Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils. J. Exp. Med., 2004-05-17;199(10):1343-54. 2004-05-17 [PMID: 15148334] (Western Blot, Human)	Western Blot	Human
Li CQ, Robles AI, Hanigan CL, Hofseth LJ, Trudel LJ, Harris CC, Wogan GN Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res., 2004-05-01;64(9):3022-9. 2004-05-01 [PMID: 15126337] (Western Blot, Human)	Western Blot	Human
Kappler M, Kotzsch M, Bartel F, Fussel S, Lautenschlager C, Schmidt U, Wurl P, Bache M, Schmidt H, Taubert H, Meye A Elevated expression level of survivin protein in soft-tissue sarcomas is a strong independent predictor of survival. Clin. Cancer Res., 2003-03-01;9(3):1098-104. 2003-03-01 [PMID: 12631613] (Western Blot, Human)	Western Blot	Human
Temme A, Rieger M, Reber F, Lindemann D, Weigle B, Diestelkoetter-Bachert P, Ehninger G, Tatsuka M, Terada Y, Rieber EP Localization, dynamics, and function of survivin revealed by expression of functional survivinDsRed fusion proteins in the living cell. Mol. Biol. Cell, 2003-01-01;14(1):78-92. 2003-01-01 [PMID: 12529428] (ICC, Human)	ICC	Human
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Reviews for Survivin Antibody (AF886) (2) 4.52

Average Rating: 4.5

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01/12/2015

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Application	Immunocytochemistry
Sample Tested	See PMID 22688671
Species	Human

reviewed by:
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Human

01/12/2015

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Application	Immunocytochemistry
Sample Tested	See PMID 23327192
Species	Human

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- The species we have listed are validated and therefore have a 100% guarantee to work with this antibody. We cannot guarantee that this will work with other species.

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Blogs on Survivin. Showing 1-10 of 16 blog posts - Show all blog posts.

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The Ins and Outs of Survivin
By Rachel M.A. Linger, Ph.D.What is survivin?Survivin is a small (16.5 kDa) protein normally found in human fetal tissue. In contrast, survivin is typically undetectable in most normal adult tissues. Expression of ... Read full blog post.

Survivin - an inhibitor of apoptosis that drives tumorigenesis and metastasis
Apoptosis is the tightly regulated process of programmed cell death. It plays an important role in normal physiologic development but has also been implicated in a number of diseases. Apoptosis is constantly downregulated by a family of anti-apop... Read full blog post.

Survivin - an inhibitor of apoptosis protein
Survivin is an anti-apoptotic protein which is the smallest protein within a large family of proteins including X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, NAIP, and Livin. Survivin is responsible for a wide range of basic cellula... Read full blog post.

Cytochrome C - a mediator of apoptosis
Cytochrome C is a small heme protein within the inner mitochondrial membrane responsible for carrying electrons within the respiratory transport chain. Additionally, cytochrome c has also been identified as a player in programmed cell death (apop... Read full blog post.

PCNA (Proliferating cell nuclear antigen, polymerase delta auxiliary protein)
PCNA is a nuclear protein essential for DNA replication as well as DNA excision and mismatch repair pathways. It coordinates the recruitment and association of needed components during both of these processes, both of which are essential for cell cycl... Read full blog post.

Survivin is thrivin'
The survivin anti-apoptotic protein is the smallest member of a large family of proteins such as X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates basic physiological events such as the cell cycle, tumor... Read full blog post.

Livin: On a Prayer
Livin is a member of the inhibitor of apoptosis proteins (IAP) family that regulates programmed cell death. The Livin protein contains a single baculovirus IAP repeat (BIR) essential for function, along with a COOH-terminal RING-type zinc finger domai... Read full blog post.

Survivin: As long as I know how to live I know I will
Survivin is an anti-apoptotic protein from a large family with related members such as X-linked IAP, cIAP1 and cIAP2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates fundamental physiological events including the cell cycle, feta... Read full blog post.

Survivin: Infographic
Survivin is involved in promoting cell proliferation and is an inhibitor of apoptosis. Survivin has a critical role in cancer proliferation and neural development. It may have an impact on neural cell proliferative responses following brain injury.L... Read full blog post.

Showing 1-10 of 16 blog posts - Show all blog posts.

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HepG2 human hepatocellular carcinoma cell line was stained with Rabbit Anti-Human Klotho beta Monoclonal Antibody (Catalog # MAB58891, filled histogram) or Rabbit IgG Isotype Control Antibody (Catalog # AB-105-C, open histogram), followed by Allophycocyanin-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # F0111). View our protocol for Staining Membrane-associated Proteins.

Rabbit IgG Isotype Control [Unconjugated]
AB-105-C

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Application:	ICC
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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Survivin Antibody [Unconjugated]

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Publications for Survivin Antibody (AF886)(99)

Reviews for Survivin Antibody (AF886) (2) 4.52

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Summary

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FAQs for Survivin Antibody (AF886). (Showing 1 - 1 of 1 FAQs).

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Blogs on Survivin. Showing 1-10 of 16 blog posts - Show all blog posts.

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