Survivin Antibody (8E2)

Survivin (BIRC5 or IAP4) is the smallest member of the inhibitor of apoptosis (IAP) proteins, containing only a single baculovirus IAP repeat (BIR) domain and lacking the C-terminal RING domain. Survivin has a theoretical molecular weight of 16.5 kDa (wild-type protein) and exists as ten splice variant forms including the most predominant isoforms, survivin-2B and surviving-DeltaEx3 (1). It also undergoes phosphorylation by PKA, Plk1, Cdk1, CKII and Aurora B at multiple sites (e.g. Serine 20 and Threonine 34, 53 and 117).

Besides being highly abundant in fetal development and expressed in proliferating adult cells such as activated T lymphocytes, erythroblasts, and self-renewing stem cells, survivin is generally absent in adult tissues. However, it is elevated in common cancers such as lung, colon, pancreas, breast and prostate where it drives proliferation, metastasis, poor prognosis, and decreased patient survival (2).

Survivin has been shown to be involved in multiple cellular processes including cell cycle progression, mitotic spindle assembly, kinetochore attachment, angiogenesis, migration, and its anti-apoptotic activity has been linked to both its monomeric and homodimeric forms. Survivin impacts the function of other IAP members, c-IAP1 and c-IAP-2, or modulates the inhibitory activity of XIAP against caspases by forming a stable complex with XIAP and HBXIP. During the intrinsic apoptotic pathway, survivin may prevent the release of mitochondrial APAF1 into the cytoplasm or hinder the association of SMAC with other IAPS, which results in prolonged cell survival (3).

References

1. Sah NK, Seniya C. (2015) Survivin splice variants and their diagnostic significance. Tumour Biol. 36(9):6623-31. PMID: 26245993

2. Lladser A, Sanhueza C, Kiessling R, Quest AF. (2011) Is survivin the potential Achilles' heel of cancer? Adv Cancer Res. 111:1-37. PMID: 21704829

3. Wheatley SP, Altieri DC. (2019) Survivin at a glance. J Cell Sci. 132(7). PMID: 30948431

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 7 applications: B/N, ELISA, FLOW, IB, ICC/IF, IF/IHC, IHC-P.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using NB500-644	Applications	Species
Rosato A, Menin C, Boldrin D et al. Survivin expression impacts prognostically on NSCLC but not SCLC Lung Cancer 2012-12-03 [PMID: 23218791] (IF/IHC, Human)	IF/IHC	Human
Biber III JC Mechanotransduction in Vascular Smooth Muscle Cells: Survivin as a Mediator of Stiffness Induced Cell Cycling and Proliferation Thesis 2023-01-01 (IB)	IB
Zeng SX, Li Y, Jin Y, Zhang Q, Keller DM, McQuaw CM, Barklis E, Stone S, Hoatlin M, Zhao Y, Lu H. Structure-specific recognition protein 1 facilitates microtubule growth and bundling required for mitosis. Mol Cell Biol30(4):935-47. 2010-02-01 [PMID: 19995907]
Fortugno P, Beltrami E, Plescia et al. Regulation of survivin function by Hsp90. Proc Natl Acad Sci U S A. 2003-11-25 [PMID: 14614132] (B/N, ELISA, Human)	B/N, ELISA	Human
Carvalho A, Carmena M, Sambade C, Earnshaw WC, Wheatley SP. Survivin is required for stable checkpoint activation in taxol-treated HeLa cells. J Cell Sci116(Pt 14):2987-98. 2003-07-15 [PMID: 12783991]
Fortugno P, Wall NR, Giodini A, O'Connor DS, Plescia J, Padgett KM, Tognin S, Marchisio PC, Altieri DC. Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function. J Cell Sci115(Pt 3):575-85. 2002-02-01 [PMID: 11861764] (ICC/IF, Human)	ICC/IF	Human
Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC. INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Curr Biol11(11):886-90. 2001-06-05 [PMID: 11516652]
Kawasaki H, Toyoda M, Shinohara H, Okuda J, Watanabe I, Yamamoto T, Tanaka K, Tenjo T, Tanigawa N. Expression of survivin correlates with apoptosis, proliferation, and angiogenesis during human colorectal tumorigenesis. Cancer91(11):2026-32. 2001-06-01 [PMID: 11391581]
Granziero L, Ghia P, Circosta P, Gottardi D, Strola G, Geuna M, Montagna L, Piccoli P, Chilosi M, Caligaris-Cappio F. Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. Blood;97(9):2777-83. 2001-05-01 [PMID: 11313271] (IHC-P, FLOW, Human)	IHC-P, FLOW	Human
O'Connor DS, Grossman D, Plescia J, Li F, Zhang H, Villa A, Tognin S, Marchisio PC, Altieri DC. Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc Natl Acad Sci U S A;97(24):13103-7. 2000-11-21 [PMID: 11069302]
Tanaka K, Iwamoto S, Gon G, Nohara T, Iwamoto M, Tanigawa N. Expression of survivin and its relationship to loss of apoptosis in breast carcinomas. Clin Cancer Res;6(1):127-34. 2000-01-01 [PMID: 10656440] (IHC-P)	IHC-P
Grossman D, McNiff JM, Li F, Altieri DC. Expression and targeting of the apoptosis inhibitor, survivin, in human melanoma. J Invest Dermatol;113(6):1076-81. 1999-12-01 [PMID: 10594755] (FLOW, Human)	FLOW	Human
Li F, Ambrosini G, Chu EY et al. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature. 1998-12-10 [PMID: 9859993] (ICC/IF, Human)	ICC/IF	Human
Kawasaki H, Altieri DC, Lu CD, Toyoda M, Tenjo T, Tanigawa N. Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer. Cancer Res58(22):5071-4. 1998-11-15 [PMID: 9823313] (IHC-P, Human)	IHC-P	Human
Lu CD, Altieri DC, Tanigawa N. Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas. Cancer Res. 1998-05-01 [PMID: 9581817] (IHC-P, ELISA, Human)	IHC-P, ELISA	Human
Show All 15 Publications. Collapse Publications.

Array NB500-644

• Survivin Antibodies
• Survivin Antibody Pack
• Survivin Lysate
• Survivin Proteins
• Survivin ELISAs
• Survivin Proteins and Enzyme