Survivin Antibody (60.11) - BSA Free

Survivin (BIRC5 or IAP4) is the smallest member of the inhibitor of apoptosis (IAP) proteins, containing only a single baculovirus IAP repeat (BIR) domain and lacking the C-terminal RING domain. Survivin has a theoretical molecular weight of 16.5 kDa (wild-type protein) and exists as ten splice variant forms including the most predominant isoforms, survivin-2B and surviving-DeltaEx3 (1). It also undergoes phosphorylation by PKA, Plk1, Cdk1, CKII and Aurora B at multiple sites (e.g. Serine 20 and Threonine 34, 53 and 117).

Besides being highly abundant in fetal development and expressed in proliferating adult cells such as activated T lymphocytes, erythroblasts, and self-renewing stem cells, survivin is generally absent in adult tissues. However, it is elevated in common cancers such as lung, colon, pancreas, breast and prostate where it drives proliferation, metastasis, poor prognosis, and decreased patient survival (2).

Survivin has been shown to be involved in multiple cellular processes including cell cycle progression, mitotic spindle assembly, kinetochore attachment, angiogenesis, migration, and its anti-apoptotic activity has been linked to both its monomeric and homodimeric forms. Survivin impacts the function of other IAP members, c-IAP1 and c-IAP-2, or modulates the inhibitory activity of XIAP against caspases by forming a stable complex with XIAP and HBXIP. During the intrinsic apoptotic pathway, survivin may prevent the release of mitochondrial APAF1 into the cytoplasm or hinder the association of SMAC with other IAPS, which results in prolonged cell survival (3).

References

1. Sah NK, Seniya C. (2015) Survivin splice variants and their diagnostic significance. Tumour Biol. 36(9):6623-31. PMID: 26245993

2. Lladser A, Sanhueza C, Kiessling R, Quest AF. (2011) Is survivin the potential Achilles' heel of cancer? Adv Cancer Res. 111:1-37. PMID: 21704829

3. Wheatley SP, Altieri DC. (2019) Survivin at a glance. J Cell Sci. 132(7). PMID: 30948431

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 9 applications: ELISA, FLOW, Flow Cytometry, ICC/IF, IF/IHC, IHC-Fr, IHC-P, PLA, WB.

Showing Publications 1 - 10 of 43. Show All 43 Publications. Collapse Publications.

Publications using NB500-238	Applications	Species
Zhang X, Ciesielski M, Fenstermaker RA et al. The Presence of Survivin on B Cells from Myasthenia Gravis Patients and the Potential of an Antibody to a Modified Survivin Peptide to Alleviate Weakness in an Animal Model The Journal of Immunology 2020-10-01 [PMID: 32839239] (Flow Cytometry)	Flow Cytometry
Kim S, Shin M, Lee A et al. Improvement of Inflammation through Antioxidant Pathway of Gardeniae Fructus 50% EtOH Extract (GE) from Acute Reflux Esophagitis Rats Biomed Res Int. [PMID: 32185206] (WB, Rat)	WB	Rat
Cho M, Lee OH, Chang EM et al. BIRC5 Expression is Regulated in Uterine Epithelium During the Estrous Cycle Genes (Basel) 2020-03-06 [PMID: 32155884] (IHC-P, Mouse)	IHC-P	Mouse
Ring A, Nguyen C, Smbatyan G et al. CBP/beta-Catenin/FOXM1 Is a Novel Therapeutic Target in Triple Negative Breast Cancer Cancers (Basel). 2018-12-19 [PMID: 30572639] (WB, Human) Details: Citation used the Unpurified format of this antibody.	WB	Human
Fenstermaker RA, Figel SA, Qiu JX et al. Survivin Monoclonal Antibodies Detect Survivin Cell Surface Expression and Inhibit Tumor Growth in vivo Clin. Cancer Res. 2018-03-14 [PMID: 29540489] (WB, Mouse)	WB	Mouse
Galbo P, Ciesielski MJ, Figel S et al. Circulating CD9+/GFAP+/survivin+ exosomes in malignant glioma patients following survivin vaccination. Oncotarget. [PMID: 29383115] (WB, Human)	WB	Human
Gallagher SJ, Gunatilake D, Beaumont KA et al. HDAC inhibitors restore BRAF-inhibitor sensitivity by altering PI3K and survival signalling in a subset of melanoma Int J Cancer 2017-12-07 [PMID: 29210065] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
Tsang TJ, Hsueh YC, Wei EI et al. Subcellular Localization of Survivin Determines Its Function in Cardiomyocytes Theranostics. 2017-10-13 [PMID: 29158846] (WB, Mouse)	WB	Mouse
BAE I, KIM C, KIM J et al. Correlation of survivin and B-cell lymphoma 2 expression with pathological malignancy and anti-apoptotic properties of glial cell tumors. BIOMEDICAL REPORTS. 2017-01-27 [PMID: 28413637] (WB, Human)	WB	Human
Dheekollu J, Malecka K, Wiedmer A et al. Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency Oncotarget 2017-01-31 [PMID: 28077791] (PLA)	PLA
The integration of a Stat3 specific peptide aptamer into the thioredoxin scaffold protein strongly enhances its inhibitory potency. Schoneberger H, Weiss A, Brill B et al. Horm Mol Biol Clin Investig [PMID: 25961238]
Valenzuela MMA, Castro I, Gonda A. Cell death in response to antimetabolites directed at ribonucleotide reductase and thymidylate synthase Onco Targets Ther 2015-02-26 [PMID: 25767396] (WB, Human)	WB	Human
Kusner LL, Ciesielski MJ, Marx A et al. Survivin as a potential mediator to support autoreactive cell survival in myasthenia gravis: a human and animal model study. PLoS ONE 2014-07-23 [PMID: 25050620] (FLOW, Human) Details: Using the DyLight 650 conjugated version of NB500-238, catalog number NB500-238C.	FLOW	Human
Kapinas Kristina, Kim Heesun, Mandeville Matthew et al. microRNA-mediated survivin control of pluripotency. J Cell Physiol. [PMID: 24891298] (Human) Details: Citation using the Unpurified form of this antibody.		Human
Rho JH, Lampe PD. High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays J Proteome Res. 2013-05-03 [PMID: 23541305] (Human) Details: A novel method using antibody microarrays is used to detect autoantibody-antigen complexes that can potentially be useful for detection and characterization of diseases.		Human
Khan S, Jutzy JM, Valenzuela MM et al. Plasma-derived exosomal survivin, a plausible biomarker for early detection of prostate cancer PLoS One 2012-01-01 [PMID: 23091600] (WB, Human)	WB	Human
Hoel AW, Yu P, Nguyen KP, et al. Mitochondrial Heat Shock Protein-90 Modulates Vascular Smooth Muscle Cell Survival and the Vascular Injury Response in Vivo. Am J Pathol. [PMID: 22841823] (IHC-Fr, WB, Human) Details: Citation using the Unpurified form of this antibody.	IHC-Fr, WB	Human
de Souza HS, West GA, Rebert N et al. Increased Levels of Survivin, via Association With Heat Shock Protein 90, in Mucosal T Cells From Patients With Crohn's Disease. Gastroenterology. [PMID: 22749932] (Human) Details: Citation using the Unpurified form of this antibody.		Human
Zhang H, Wang Y, Liu C et al. DNA and adenovirus tumor vaccine expressing truncated survivin generates specific immune responses and anti-tumor effects in a murine melanoma model Cancer Immunol Immunother 2012-06-17 [PMID: 22706381] (WB, Human)	WB	Human
Lopergolo A, Tavecchio M, Lisanti S et al. Chk2 phosphorylation of survivin-DeltaEx3 contributes to a DNA damage-sensing checkpoint in cancer. Cancer Res 2012-07-01 [PMID: 22586065] (IF/IHC, Human)	IF/IHC	Human
Keerthivasan G, Liu H, Gump JM et al. A novel role for survivin in erythroblast enucleation Haematologica 2012-10-01 [PMID: 22491741] (ICC/IF, WB, Mouse)	ICC/IF, WB	Mouse
Sakao K, Desineni S, Hahm ER, Singh SV. Phenethyl isothiocyanate suppresses inhibitor of apoptosis family protein expression in prostate cancer cells in culture and in vivo. Prostate. 2011-12-07 [PMID: 22161756] (WB, IF/IHC, Mouse, Human)	WB, IF/IHC	Mouse, Human
Femia AP, Salvianti F, Luceri C et al. Sustained proliferation and resistance to apoptosis after a cytotoxic insult are early alterations in rat colon carcinogenesis. Int J Cancer;131(3):529-36. 2012-08-01 [PMID: 21976248] (IHC-P, Rat)	IHC-P	Rat
Lechler P, Balakrishnan S, Schaumburger J et al. The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro. BMC Musculoskelet Disord. 2011-07-05 [PMID: 21729321] (ICC/IF, Human)	ICC/IF	Human
Lechler P, Schaumburger J, Kock FX et al. The Oncofetal Gene Survivin Promotes Cell Proliferation and Survival in Primary Human Osteoblastic Cells. Calcif Tissue Int. 2011-06-15 [PMID: 21674243] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Lechler P, Renkawitz T, Campean V et al. The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro. BMC Cancer11(1):120. 2011-04-02 [PMID: 21457573] (IHC-P, WB, ICC/IF, Human)	IHC-P, WB, ICC/IF	Human
Knauer SK, Heinrich UR, Bier C et al. An otoprotective role for the apoptosis inhibitor protein survivin. Cell Death Dis . [PMID: 21364656] Details: Citation using the Unpurified form of this antibody.
Habtemichael N, Wunsch D, Bier C et al. Cloning and functional characterization of the guinea pig apoptosis inhibitor protein Survivin. Gene. [PMID: 20727954] Details: Citation using the Unpurified form of this antibody.
Habtemichael N, Heinrich UR, Knauer SK et al. Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear. Mol Cell Neurosci . [PMID: 20627126] Details: Citation using the Unpurified form of this antibody.
Jiang X, Gwye Y et al. CD133 expression in chemo-resistant Ewing sarcoma cells. BMC Cancer 2010-03-26 [PMID: 20346143] (WB, Human)	WB	Human
Huang H, Fletcher L, Beeharry N et al. Abnormal cytokinesis after X-irradiation in tumor cells that override the G2 DNA damage checkpoint. Cancer Res. [PMID: 18483255] (ICC/IF, Human) Details: Citation using the Unpurified form of this antibody.	ICC/IF	Human
Levkau B, Schafers M, Wohlschlaeger J et al. Survivin determines cardiac function by controlling total cardiomyocyte number. Circulation. [PMID: 18332262] (WB, IHC-P, Human) Details: Citation using the Unpurified form of this antibody.	WB, IHC-P	Human
Hino R, Uozaki H, Inoue Y et al. Survival advantage of EBV-associated gastric carcinoma: survivin up-regulation by viral latent membrane protein 2A. Cancer Res. [PMID: 18316606] (ICC/IF, WB, Human) Details: Citation using the Unpurified form of this antibody.	ICC/IF, WB	Human
Brocardo M et al. Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival. J Biol Chem283(9):5950-9. 2008-02-29 [PMID: 18160396]
Lechler P, Wu X, Bernhardt W et al. The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney. Am J Pathol171(5):1483-98. 2007-11-01 [PMID: 17982126] (IHC-P, WB, Mouse, Human)	IHC-P, WB	Mouse, Human
Ryan, B et al. Expression of survivin and its splice variants survivin-2B and survivin-DeltaEx3 in breast cancer. Br J Cancer92(1):120-4. 2005-01-17 [PMID: 15611790]
Ansell, S et al. Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin's lymphoma. Leukemia. [PMID: 14749704] (WB, Human) Details: Citation using the Unpurified form of this antibody.	WB	Human
Koyama S. Differential expression of intracellular apoptotic signaling molecules in tumor and tumor-infiltrating lymphocytes during development of invasion and/or metastasis of gastric carcinoma. Dig Dis Sci48(12):2290-300. 2003-12-01 [PMID: 14714615] (FLOW, Human)	FLOW	Human
Ku JH, Kwak C, Lee HS, Park HK, Lee E, Lee SE. Expression of survivin, a novel inhibitor of apoptosis, in superficial transitional cell carcinoma of the bladder. J Urol171(2 Pt 1):631-5. 2004-02-01 [PMID: 14713775]
Xu, Z et al. Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression. J Biol Chem279(3):1838-44. 2004-01-16 [PMID: 14597622]
Allen, S et al. Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression. Cancer Res63(3):567-72. 2003-02-01 [PMID: 12566297] (IHC-P, Mouse)	IHC-P	Mouse
Fortugno P, Wall NR, Giodini A, O'Connor DS, Plescia J, Padgett KM, Tognin S, Marchisio PC, Altieri DC. Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function. J Cell Sci115(Pt 3):575-85. 2002-02-01 [PMID: 11861764] (ELISA, WB, Human)	ELISA, WB	Human
Zhu, L et al. Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning. FEBS Lett508(3):369-74. 2001-11-23 [PMID: 11728454]
Show All 43 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	3 reviewed by: Verified Customer	MiAr	Human	12/04/2018	View Summary Application Microarray Sample Tested EDTA Plasma Species Human Lot B1
Enlarge	4 reviewed by: Verified Customer	WB	Human	08/24/2017	View Summary Application Western Blot Sample Tested Human Breast Cancer Cell line SKBR3 cell lysates Species Human Lot Lot B
	4 reviewed by: Verified Customer	WB	Mouse	12/08/2011	View Summary Application Western Blot Sample Tested Mouse heart Species Mouse

Array NB500-238

• Survivin Antibodies
• Survivin Antibody Pack
• Survivin Lysate
• Survivin Proteins
• Survivin ELISAs
• Survivin Proteins and Enzyme