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StAR Antibody (STAR/2140) [Janelia Fluor® 585]

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Summary
Product Discontinued
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    • Catalog Number
      NBP2-75740JF585
    • Availability
      Product Discontinued

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StAR Antibody (STAR/2140) [Janelia Fluor® 585] Summary

Immunogen
Recombinant fragment (around aa 39-108) of human StAR protein (exact sequence is proprietary) (Uniprot: P49675)
Localization
Cytoplasmic (Mitochondria)
Marker
Leydig Cell Marker
Specificity
Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone. It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
STAR
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Protein Array
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for StAR Antibody (STAR/2140) [Janelia Fluor® 585]

  • cholesterol trafficker
  • mitochondrial steroid acute regulatory protein
  • StAR
  • StARD1
  • STARD1StAR-related lipid transfer (START) domain containing 1
  • START domain containing 1
  • START domain-containing protein 1
  • steroid acute regulatory protein
  • steroidogenic acute regulator
  • steroidogenic acute regulatory protein
  • steroidogenic acute regulatory protein, mitochondrial

Background

StAR is encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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StAR Antibody
(STAR/2140) [Janelia ...
NBP2-75740JF585
StAR Antibody (STAR/2140) [Janelia Fluor® 585]
Species: Hu
Applications: IHC, MA

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Bioinformatics

Gene Symbol STAR