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Stanniocalcin 2/STC-2 Antibody [Unconjugated]

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STC2 expression in tumor adjacent nasopharyngeal epithelia with normal morphology and carcinoma cells as determined by immunohistochemistry studies. A: STC2 expressed in local tumor (× 200). B: Traditional HE staining, NPC, (× 200). C: STC2 was overexpressed in the tumor zone (× 100). D: Negative Control: NPC tissue stained at the same conditions except that no specific antibody (anti-STC2) was added (× 100). Scale bar: 50 μm in A and B; 100 μm in C and D. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/24606961), licensed under a CC-BY license. Not internally tested by R&D Systems.
STC2 expression in tumor adjacent nasopharyngeal epithelia with normal morphology and carcinoma cells as determined by immunohistochemistry studies. A: STC2 expressed in local tumor (× 200). B: Traditional HE staining, ...read more
STC2 expression in tumor adjacent nasopharyngeal epithelia with normal morphology and carcinoma cells as determined by immunohistochemistry studies. A: STC2 expressed in local tumor (× 200). B: Traditional HE staining, ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Biotin
BAF2830
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
AF2830-SP
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Stanniocalcin 2/STC-2 Antibody [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Stanniocalcin 2/STC‑2
Thr25-Arg302
Accession # O76061
Specificity
Detects human and mouse Stanniocalcin 2/STC‑2 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross‑reactivity with recombinant human STC-1 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
STC2
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
Publications
Read Publications using
AF2830 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Stanniocalcin 2/STC-2 Antibody [Unconjugated]

  • Stanniocalcin 2
  • stanniocalcin-2
  • STC2
  • STC-2
  • STC-2Stanniocalcin-related protein
  • STC-related protein
  • STCRP

Background

STC-2 is a secreted disulfide-linked homodimeric glycoprotein hormone that is related to the STC protein first discovered from corpuscles of stannius in fish. STC2 is expressed in a wide variety of tissues. In the ovary, STC2 has been shown to be a paracrine hormone that regulates granulosa cell function. The amino acid sequence of human mature STC2 is 36% identical to that of human STC1. It is also 99%, and 88% identical to that of mature monkey and mouse STC2, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Stanniocalcin 2/STC-2 Antibody (AF2830)(4)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IHC, Western Blot.


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IHC
(1)
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(3)
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(3)
Mouse
(1)
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Showing Publications 1 - 4 of 4.
Publications using AF2830 Applications Species
E Marouli, M Graff, C Medina-Gom, KS Lo, AR Wood, TR Kjaer, RS Fine, Y Lu, C Schurmann, HM Highland, S Reger, G Thorleifss, AE Justice, D Lamparter, KE Stirrups, V Turcot, KL Young, TW Winkler, T Esko, T Karaderi, AE Locke, NG Masca, MC Ng, P Mudgal, MA Rivas, S Vedantam, A Mahajan, X Guo, G Abecasis, KK Aben, LS Adair, DS Alam, E Albrecht, KH Allin, M Allison, P Amouyel, EV Appel, D Arveiler, FW Asselbergs, PL Auer, B Balkau, B Banas, LE Bang, M Benn, S Bergmann, LF Bielak, M Blher, H Boeing, E Boerwinkle, CA B”ger, LL Bonnycastl, J Bork-Jense, ML Bots, EP Bottinger, DW Bowden, I Brandslund, G Breen, MH Brilliant, L Broer, AA Burt, AS Butterwort, DJ Carey, MJ Caulfield, JC Chambers, DI Chasman, YI Chen, R Chowdhury, C Christense, AY Chu, M Cocca, FS Collins, JP Cook, J Corley, JC Galbany, AJ Cox, G Cuellar-Pa, J Danesh, G Davies, PI de Bakker, GJ de Borst, S de Denus, MC de Groot, R de Mutsert, IJ Deary, G Dedoussis, EW Demerath, AI den Hollan, JG Dennis, E Di Angelan, F Drenos, M Du, AM Dunning, DF Easton, T Ebeling, TL Edwards, PT Ellinor, P Elliott, E Evangelou, AE Farmaki, JD Faul, MF Feitosa, S Feng, E Ferrannini, MM Ferrario, J Ferrieres, JC Florez, I Ford, M Fornage, PW Franks, R Frikke-Sch, TE Galesloot, W Gan, I Gandin, P Gasparini, V Giedraitis, A Giri, G Girotto, SD Gordon, P Gordon-Lar, M Gorski, N Grarup, ML Grove, V Gudnason, S Gustafsson, T Hansen, KM Harris, TB Harris, AT Hattersley, C Hayward, L He, IM Heid, K Heikkil„, ? Helgeland, J Hernesniem, AW Hewitt, LJ Hocking, M Hollensted, OL Holmen, GK Hovingh, JM Howson, CB Hoyng, PL Huang, K Hveem, MA Ikram, E Ingelsson, AU Jackson, JH Jansson, GP Jarvik, GB Jensen, MA Jhun, Y Jia, X Jiang, S Johansson, ME J?rgensen, T J?rgensen, P Jousilahti, JW Jukema, B Kahali, RS Kahn, M K„h”nen, PR Kamstrup, S Kanoni, J Kaprio, M Karalefthe, SL Kardia, F Karpe, F Kee, R Keeman, LA Kiemeney, H Kitajima, KB Kluivers, T Kocher, P Komulainen, J Kontto, JS Kooner, C Kooperberg, P Kovacs, J Kriebel, H Kuivaniemi, S Kry, J Kuusisto, M La Bianca, M Laakso, TA Lakka, EM Lange, LA Lange, CD Langefeld, C Langenberg, EB Larson, IT Lee, T Lehtim„ki, CE Lewis, H Li, J Li, R Li-Gao, H Lin, LA Lin, X Lin, L Lind, J Lindstr”m, A Linneberg, Y Liu, Y Liu, A Lophatanan, J Luan, SA Lubitz, LP Lyytik„ine, DA Mackey, PA Madden, AK Manning, S M„nnist”, G Marenne, J Marten, NG Martin, AL Mazul, K Meidtner, A Metspalu, P Mitchell, KL Mohlke, DO Mook-Kanam, A Morgan, AD Morris, AP Morris, M Mller-Nur, PB Munroe, MA Nalls, M Nauck, CP Nelson, M Neville, SF Nielsen, K Nikus, PR Nj?lstad, BG Nordestgaa, I Ntalla, JR O'Connel, H Oksa, LM Loohuis, RA Ophoff, KR Owen, CJ Packard, S Padmanabha, CN Palmer, G Pasterkamp, AP Patel, A Pattie, O Pedersen, PL Peissig, GM Peloso, CE Pennell, M Perola, JA Perry, JR Perry, TN Person, A Pirie, O Polasek, D Posthuma, OT Raitakari, A Rasheed, R Rauramaa, DF Reilly, AP Reiner, F Renstr”m, PM Ridker, JD Rioux, N Robertson, A Robino, O Rolandsson, I Rudan, KS Ruth, D Saleheen, V Salomaa, NJ Samani, K Sandow, Y Sapkota, N Sattar, MK Schmidt, PJ Schreiner, MB Schulze, RA Scott, MP Segura-Lep, S Shah, X Sim, S Sivapalara, KS Small, AV Smith, JA Smith, L Southam, TD Spector, EK Speliotes, JM Starr, V Steinthors, HM Stringham, M Stumvoll, P Surendran, LM 't Hart, KE Tansey, JC Tardif, KD Taylor, A Teumer, DJ Thompson, U Thorsteins, BH Thuesen, A T”njes, G Tromp, S Trompet, E Tsafantaki, J Tuomilehto, A Tybjaerg-H, JP Tyrer, R Uher, AG Uitterlind, S Ulivi, SW van der La, AR Van Der Le, CM van Duijn, NM van Schoor, J van Setten, A Varbo, TV Varga, R Varma, DR Edwards, SH Vermeulen, H Vestergaar, V Vitart, TF Vogt, D Vozzi, M Walker, F Wang, CA Wang, S Wang, Y Wang, NJ Wareham, HR Warren, J Wessel, SM Willems, JG Wilson, DR Witte, MO Woods, Y Wu, H Yaghootkar, J Yao, P Yao, LM Yerges-Arm, R Young, E Zeggini, X Zhan, W Zhang, JH Zhao, W Zhao, W Zhao, H Zheng, W Zhou, JI Rotter, M Boehnke, S Kathiresan, MI McCarthy, CJ Willer, K Stefansson, IB Borecki, DJ Liu, KE North, NL Heard-Cost, TH Pers, CM Lindgren, C Oxvig, Z Kutalik, F Rivadeneir, RJ Loos, TM Frayling, JN Hirschhorn, P Deloukas, G Lettre Rare and low-frequency coding variants alter human adult height Nature, 2017-02-01;0(0):. 2017-02-01 [PMID: 28146470] (Western Blot, Human) Western Blot Human
Kloverpris S, Mikkelsen J, Pedersen J, Jepsen M, Laursen L, Petersen S, Oxvig C Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A. J Biol Chem, 2015-07-20;290(36):21915-24. 2015-07-20 [PMID: 26195635] (Western Blot, Human) Western Blot Human
Jepsen M, Kloverpris S, Mikkelsen J, Pedersen J, Fuchtbauer E, Laursen L, Oxvig C Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis. J Biol Chem, 2014-12-22;290(6):3430-9. 2014-12-22 [PMID: 25533459] (Western Blot, Mouse) Western Blot Mouse
Lin S, Guo Q, Wen J, Li C, Lin J, Cui X, Sang N, Pan J Survival analyses correlate stanniocalcin 2 overexpression to poor prognosis of nasopharyngeal carcinomas. J Exp Clin Cancer Res, 2014-03-08;33(0):26. 2014-03-08 [PMID: 24606961] (IHC, Human) IHC Human

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Bioinformatics

Gene Symbol STC2
Uniprot