Somatostatin R2/SSTR2 Antibody

Somatostatin Receptor Type 2 (SST2) expression has been reported in adrenal, aorta, brain, breast, eye, gastrointestinal tract, pancreas, prostate, spinal cord, and thyroid. ESTs have been isolated from brain, eye, head/neck, kidney, lymph node, pineal, and prostate libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 3 applications: ICC/IF, IF/IHC, IHC-P.

Showing Publications 1 - 6 of 6.

Publications using NB100-74537	Applications	Species
Waser B, Cescato R, Liu Q et al. Phosphorylation of sst2 receptors in neuroendocrine tumors after octreotide treatment of patients. Am J Pathol 2012-05-01 [PMID: 22538189] (Human)		Human
Garrido JM, Sevilla IA, Beltran-Beck B et al. Protection against tuberculosis in Eurasian wild boar vaccinated with heat-inactivated Mycobacterium bovis. PLoS One 2011-01-01 [PMID: 21935486]
Johnson DR, Kimmel DW, Burch PA, Cascino TL, Giannini C, Wu W, Buckner JC. Phase II study of subcutaneous octreotide in adults with recurrent or progressive meningioma and meningeal hemangiopericytoma. Neuro Oncol;13(5):530-5. 2011-05-01 [PMID: 21558077] (IF/IHC, Human)	IF/IHC	Human
Rodriguez-Moldes I, Carrera I, Pose-Mendez S, et al. Regionalization of the shark hindbrain: a survey of an ancestral organization Front Neuroanat 2011-03-01 [PMID: 21519383]
Kao YJ, Ghosh M, Schonbrunn A. Ligand-dependent mechanisms of sst2A receptor trafficking: role of site-specific phosphorylation and receptor activation in the actions of biased somatostatin agonists Mol Endocrinol 2011-06-01 [PMID: 21493671] (ICC/IF, Rat)	ICC/IF	Rat
Agool A, Slart RH, Dierckx RA et al. Somatostatin receptor scintigraphy might be useful for detecting skeleton abnormalities in patients with multiple myeloma and plasmacytoma. Eur J Nucl Med Mol Imaging 2010-01-01 [PMID: 19597816] (IHC-P, Human)	IHC-P	Human

Array NB100-74537

• Somatostatin R2/SSTR2 Antibodies
• Somatostatin R2/SSTR2 ELISA Kit
• Somatostatin R2/SSTR2 Lysate
• Somatostatin R2/SSTR2 Proteins