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SMAC/Diablo Antibody (006) [DyLight 650]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, Flow, ICC/IF
Clone
006
Clonality
Monoclonal
Host
Rabbit
Conjugate
DyLight 650

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-89251AF350
Alexa Fluor 405
NBP2-89251AF405
Alexa Fluor 488
NBP2-89251AF488
Alexa Fluor 532
NBP2-89251AF532
Alexa Fluor 594
NBP2-89251AF594
Alexa Fluor 647
NBP2-89251AF647
Alexa Fluor 700
NBP2-89251AF700
Alexa Fluor 750
NBP2-89251AF750
Allophycocyanin
NBP2-89251APC
Biotin
NBP2-89251B
DyLight 350
NBP2-89251UV
DyLight 405
NBP2-89251V
DyLight 488
NBP2-89251G
DyLight 550
NBP2-89251R
DyLight 594
NBP2-89251DL594
DyLight 680
NBP2-89251FR
DyLight 755
NBP2-89251IR
FITC
NBP2-89251F
HRP
NBP2-89251H
Janelia Fluor 549
NBP2-89251JF549
Janelia Fluor 646
NBP2-89251JF646
PE
NBP2-89251PE
PerCP
NBP2-89251PCP
Unconjugated
NBP2-89251-100ul
mFluor Violet 450 SE
NBP2-89251MFV450
mFluor Violet 500 SE
NBP2-89251MFV500
mFluor Violet 610 SE
NBP2-89251MFV610
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SMAC/Diablo Antibody (006) [DyLight 650] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
This antibody was obtained from a rabbit immunized with purified, recombinant Human SMAC/Diablo (Accession#: NP_063940.1; Ala 56-Asp 239).
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
DIABLO
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for SMAC/Diablo Antibody (006) [DyLight 650]

  • 0610041G12Rik
  • Diablo
  • diablo, IAP-binding mitochondrial protein
  • Direct IAP-binding protein with low pI
  • mitochondrial Smac protein
  • Second mitochondria-derived activator of caspase
  • SMAC
  • SMACmitochondrial

Background

Smac/DIABLO is a mitochondrial protein which activates various forms of apoptosis. Specifically, Smac exits the mitochondria and enters the cytosol where it initiates apoptosis by neutralizing members of the IAP family of apoptosis inhibitory proteins. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Blogs on SMAC/Diablo.

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Apoptosis and Necroptosis Part II: Inhibitors of apoptosis proteins (IAPs); Key regulators of the balance between necroptosis, apoptosis and survival
In the first installment of this two-part blog post titled "Apoptosis and Necroptosis: Important factors to identify both types of programmed cell death", the mechanisms by which cell death occurs and ways to identify these pathways were ...  Read full blog post.
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Bioinformatics

Gene Symbol DIABLO