SHANK3 Antibody (S69)

Function: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.; Subcellular location: Cytoplasm. Cell junction synapse. Cell junction synapse postsynaptic cell membrane postsynaptic density. Note: Postsynaptic density of neuronal cells. Extends into the region subjacent to the PSD.; Tissue specificity: Widely expressed in brain.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: WB, Western Blot.

Showing Publications 1 - 3 of 3.

Publications using NBP1-47610	Applications	Species
ElAli A, Menet R, Bernard M et al. Myeloid dickkopf-1 fuels neurovascular and neuroimmune alterations in ischemic stroke Research Square 2023-08-14 (Western Blot, Mouse)	Western Blot	Mouse
Landry O, François A, Oye Mintsa Mi-Mba MF et al. Postsynaptic Protein Shank3a Deficiency Synergizes with Alzheimer's Disease Neuropathology to Impair Cognitive Performance in the 3xTg-AD Murine Model The Journal of neuroscience : the official journal of the Society for Neuroscience 2023-06-28 [PMID: 37253603] (WB, Mouse)	WB	Mouse
Mayanagi T, Yasuda H, Sobue K. PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity. J Neurosci 2015-10-21 [PMID: 26490870]

Array NBP1-47610

• SHANK3 Antibodies