Recombinant Human Serum Amyloid A1 Protein

This lyophilized preparation is stable for 12 months from date of receipt at -20 to -70 degrees C, preferably desiccated. Upon reconstitution, the preparation can be stored for 1 month at 2-8 degrees C under sterile conditions, and for 3 months at -20 degrees C to -70 degrees C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Stock solutions should be aliquoted and stored at < -20 degrees C. Further dilutions should be made in appropriate buffered solutions

Serum Amyloid A protein-1 (SAA1) is a multifunctional apolipoprotein that circulates as part of the HDL complex. It can displace ApoA1 as the major apolipoprotein in HDL complexes and reduce the capacity of HDL for reverse cholesterol transport. In response to proinflammatory cytokines, SAA1 is prominently produced in liver and also in human but not mouse adipose tissue. Circulating SAA1 levels can increase by as much as 1000-fold during inflammation. SAA1 induces monocyte and macrophage chemotaxis and activation through binding to CD36/SR-B3, SR-B1, FPRL1, TLR2, and RAGE. It can also opsonize and promote the clearance of Gram negative bacteria.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

We have publications tested in 1 application: WB.

Showing Publication 1 - 1 of 1.

Publication using NBP2-34875	Applications	Species
Siman-Tov R, Shalabi R, Shlomai A et al. Elevated Serum Amyloid A Levels Contribute to Increased Platelet Adhesion in COVID-19 Patients International journal of molecular sciences 2022-11-17 [PMID: 36430724] (WB)	WB

Array NBP2-34875

• Serum Amyloid A1 Antibodies
• Serum Amyloid A1 Lysates
• Serum Amyloid A1 Proteins
• Serum Amyloid A1 Proteins and Enzyme
• Serum Amyloid A1 ELISA