SAMHD1 Antibody (883335) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human SAM (Sterile Alpha Motif) domain and HD (His/Asp motif-containing phosphohydrolase) domain-containing 1 (SAMHD1), also known as DCIP (dendritic cell IFN-g-induced protein) or MOP5 (monocyte protein 5) is a 70-80 kDa, 626 amino acid (aa) nuclear protein that acts as a dGTP-regulated deoxynucleotide triphosphohydrolase. It restricts HIV replication by binding nucleic acids. SAMHD-1 expression is induced by TNF-a in myeloid lineage cells and lung fibroblasts. Human SAMHD1 mutations are linked to Aicardi-Goutieres Syndrome, which is characterized by symptoms mimicking viral infection. Human SAMHD1 isoforms of 602, 591, and 556 aa lack aa 113-136, 502-536, and 285-354, respectively. The 591 and 556 aa forms are catalytically inactive. Within the region used as an immunogen, human SAMHD1 shares 85% aa sequence identity with mouse and rat SAMHD1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB8120

• SAMHD1 Antibodies
• SAMHD1 Lysate
• SAMHD1 Proteins