RPL7 Antibody

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 5 of 5.

Publications using NB100-2268	Applications	Species
Girgis S, Xu Z, Oikonomopoulos S et al. Evolution of naturally arising SARS-CoV-2 defective interfering particles Communications biology 2022-10-27 [PMID: 36302891] (WB, Human)	WB	Human
O'Leary MN, Schreiber KH, Zhang Y et al. The Ribosomal Protein Rpl22 Controls Ribosome Composition by Directly Repressing Expression of Its Own Paralog, Rpl22l1. PLoS Genet. 2013-08-01 [PMID: 23990801] (WB, Mouse)	WB	Mouse
Milev MP, Ravichandran M, Khan MF et al. Characterization of Staufen1 Ribonucleoproteins by Mass Spectrometry and Biochemical Analyses Reveal the Presence of Diverse Host Proteins Associated with Human Immunodeficiency Virus Type 2 Front Microbiol 2012-01-01 [PMID: 23125841] (WB, Human)	WB	Human
Sanz E, Yang L, Su T et al. Cell-type-specific isolation of ribosome-associated mRNA from complex tissues. PNAS;106(33):13939-13944. 2009-01-01 [PMID: 19666516]
Maggi LB Jr, Kuchenruether M, Dadey DY et al. Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol Cell Biol 2008-12-01 [PMID: 18809582]

Array NB100-2268

• RPL7 Antibodies
• RPL7 Proteins