Relaxin R1/LGR7 Antibody

The relaxin receptor, RXFP1, has recently been identified as the only human G-protein-coupled receptor to contain a low-density lipoprotein class-A (LDL-A) module. The mosaic protein contains an N-terminal low density lipoprotein (LDL) receptor cysteine-rich motif, a set of ten leucine-rich repeats and a seven transmembrane region with an intracellular C-terminus. RXFP1 specifically binds relaxins H1 and H2 with high affinity and thus stimulates adenylate cyclase activation, substrate adhesion, and chemo migratory capacity of mononuclear leukocytes. RXFP1 is critical for mediating these biological responses by use of RNA interference lentiviral short hairpin constructs. The gene encoding for RXFP1 is mapped to the 4q32.1 region of the chromosome. The protein is commonly expressed in human brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Canine.

We have publications tested in 3 applications: IF/IHC, IHC-Fr, WB.

Showing Publications 1 - 2 of 2.

Publications using NBP2-23674	Applications	Species
Restucci B, Sgadari M, Fatone G et al. Immunoexpression of Relaxin and Its Receptors in Stifle Joints of Dogs with Cranial Cruciate Ligament Disease Animals 2022-03-23 [PMID: 35405809] (IF/IHC, WB, Canine)	IF/IHC, WB	Canine
Gao XM, Su Y, Moore S et al. Relaxin mitigates microvascular damage and inflammation following cardiac ischemia-reperfusion Basic Res. Cardiol. 2019-06-19 [PMID: 31218471] (IHC-Fr, WB, Mouse)	IHC-Fr, WB	Mouse

Array NBP2-23674

• Relaxin R1/LGR7 Antibodies
• Relaxin R1/LGR7 ELISA Kits
• Relaxin R1/LGR7 Lysate
• Relaxin R1/LGR7 Protein
• Relaxin R1/LGR7 Proteins and Enzyme