Recombinant Mouse Neuregulin-1/NRG1 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Neuregulin-1 (NRG1) belongs to a family of structurally related glycoproteins encoded by four distinct but related genes, Nrg1, Nrg2, Nrg3, and Nrg4. In humans, Nrg1 encodes multiple soluble or transmembrane proteins through alternative splicing or the use of alternative promoters with each NRG1 isoform exhibiting distinct expression patterns and functions (1). Type I isoforms include Neu Differentiation Factor, Heregulin, and ARIA, and they consist of an N-terminal domain, an Ig-like domain, a linker with a Ser/Thr rich region, an EGF-like domain, a transmembrane segment, and a cytoplasmic domain. Type II isoforms have a larger N-terminal domain and lack the Ser/Thr rich linker, while Type III isoforms lack the Ig-like domain but contain a cysteine rich domain (CRD) and a second transmembrane segment (1-6). The mature mouse NRG1 isoform expressed corresponds to Heregulin-beta 1 with an extracellular domain of 229 amino acids (aa) that shares 92% and 79% sequence identity with human and rat NRG1, respectively. NRG1 regulates multiple nervous system functions including axon guidance, synapse formation and plasticity, glial cell development, and axon myelination (1-3). All NRG1 isoforms share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors to induce signaling (1-4). Heregulin-beta 1 has been directly linked to diverse functions including cardiovascular development and protection from ischemic injury (7) to a role in the growth and maintenance of human embryonic stem cells (8). Multiple polymorphisms and aberrant expression of NRG1 isoforms are associated with the development of schizophrenia and several cancers (2, 9, 10). Activation of Heregulin-beta 1 signaling has been shown to promote invasiveness and metastasis of breast cancer cells (11, 12).

We have publications tested in 3 confirmed species: Mouse, Rat, Transgenic Mouse.

We have publications tested in 4 applications: Bioassay, Cell Culture, In Vivo, In vivo assay.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using 9875-NR	Applications	Species
Bergersen, KV;Kavvathas, B;Ford, BD;Wilson, EH; Toxoplasma infection induces an aged neutrophil population in the CNS that is associated with neuronal protection Journal of neuroinflammation 2024-08-02 [PMID: 39095837] (In vivo assay, Mouse)	In vivo assay	Mouse
Hoving, JJA;Harford-Wright, E;Wingfield-Digby, P;Cattin, AL;Campana, M;Power, A;Morgan, T;Torchiaro, E;Quereda, V;Lloyd, AC; N-cadherin directs the collective Schwann cell migration required for nerve regeneration through Slit2/3-mediated contact inhibition of locomotion eLife 2024-04-09 [PMID: 38591541] (Bioassay, Mouse)	Bioassay	Mouse
Chougoni, KK;Park, H;Damle, PK;Mason, T;Cheng, B;Dcona, MM;Szomju, B;Dozmorov, MG;Idowu, MO;Grossman, SR; Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma Oncogenesis 2023-11-10 [PMID: 37949862] (Bioassay, Mouse)	Bioassay	Mouse
Patel, S;Sparman, NZR;Arneson, D;Alvarsson, A;Santos, LC;Duesman, SJ;Centonze, A;Hathaway, E;Ahn, IS;Diamante, G;Cely, I;Cho, CH;Talari, NK;Rajbhandari, AK;Goedeke, L;Wang, P;Butte, AJ;Blanpain, C;Chella Krishnan, K;Lusis, AJ;Stanley, SA;Yang, X;Rajbhandari, P; Mammary duct luminal epithelium controls adipocyte thermogenic programme Nature 2023-07-26 [PMID: 37495690] (Cell Culture, Mouse)	Cell Culture	Mouse
Andries, L;Kancheva, D;Masin, L;Scheyltjens, I;Van Hove, H;De Vlaminck, K;Bergmans, S;Claes, M;De Groef, L;Moons, L;Movahedi, K; Immune stimulation recruits a subset of pro-regenerative macrophages to the retina that promotes axonal regrowth of injured neurons Acta neuropathologica communications 2023-05-24 [PMID: 37226256] (In Vivo, Mouse)	In Vivo	Mouse
C Chiasson-M, J Vitte, CH Liu, EA Wright, EA Flynn, SL Stott, M Giovannini, AI McClatchey Cellular mechanisms of heterogeneity in NF2-mutant schwannoma Nature Communications, 2023-03-21;14(1):1559. 2023-03-21 [PMID: 36944680] (Bioassay, Mouse)	Bioassay	Mouse
S Banerjee, S Mishra, W Xu, WE Thompson, I Chowdhury Neuregulin-1 signaling regulates cytokines and chemokines expression and secretion in granulosa cell Journal of ovarian research, 2022-07-26;15(1):86. 2022-07-26 [PMID: 35883098] (Bioassay, Rat)	Bioassay	Rat
F Westendorp, ON Karpus, PJ Koelink, JLM Vermeulen, S Meisner, J Koster, NVJA Büller, ME Wildenberg, V Muncan, GR van den Br Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation Oncogene, 2021-01-21;0(0):. 2021-01-21 [PMID: 33479497] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
TC Huang, HL Wu, SH Chen, YT Wang, CC Wu Thrombomodulin facilitates peripheral nerve regeneration through regulating M1/M2 switching J Neuroinflammation, 2020-08-14;17(1):240. 2020-08-14 [PMID: 32799887] (Bioassay, Rat)	Bioassay	Rat
C Gomis-Colo, S Velasco-Av, JA Gomez-Sanc, A Casillas-B, J Backs, H Cabedo Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells J. Cell Biol., 2018-02-22;0(0):. 2018-02-22 [PMID: 29472387] (Bioassay, Rat)	Bioassay	Rat
RC Cornelison, E Gonzalez-R, SL Porvasnik, SM Wellman, JH Park, DD Fuller, CE Schmidt Injectable hydrogels of optimized acellular nerve for injection in the injured spinal cord Biomed Mater, 2018-03-21;0(0):. 2018-03-21 [PMID: 29380749] (Cell Culture, Rat)	Cell Culture	Rat
Show All 11 Publications. Collapse Publications.

Array 9875-NR

• Neuregulin-1/NRG1 Antibodies
• Neuregulin-1/NRG1 ELISA Kits
• Neuregulin-1/NRG1 Lysates
• Neuregulin-1/NRG1 Proteins and Enzymes