Neuregulin-1/NRG1 Products

Description

Neuregulin 1 (NRG1, isoform HRG-beta2) belongs to the neuregulin/heregulin cytokine family consisting of variants of the four genes NRG1, NRG2, NRG3 and NRG4. More than 15 transmembrane and secreted protein isoforms exist for NRG1, they are generated by alternative promoter usage and mRNA splicing. The different isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. The EGF-like domain interacts with ErbB3 and ErbB4 tyrosine kinase receptors, resulting in tyrosine phosphorylation and NRG1 signaling. NRG proteins show distinct spatial and temporal expression patterns. These proteins are important for the development of the nervous system and the heart and in the regulation of neurotransmission.

Bioinformatics

Uniprot	AAA58639 Human AAH07675 Human NM_013956 Human NP_039252 Human NP_039258 Human P08311 Human Q02297 Human Q15491 Human
Product By Gene ID	3084
Alternate Names	ARIA GGF2 GGFglial growth factor HGLneu differentiation factor HRG HRG1 HRGAneuregulin 1 type IV beta 1a MST131 MSTP131 NDFheregulin, alpha (45kD, ERBB2 p185-activator) neuregulin 1 type IV beta 3 neuregulin 1 pro-neuregulin-1, membrane-bound isoform pro-NRG1 Pro-NRG1 sensory and motor neuron derived factor SMDF

Research Areas for Neuregulin-1/NRG1

Find related products by research area and learn more about each of the different research areas below.

Biologically Active Proteins
Chromatin Research
Glia Markers
Growth and Development
Neuronal Cell Markers
Neuroscience
Oligodendrocyte Cell Markers
Signal Transduction