Recombinant Mouse CD30 Ligand/TNFSF8 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD30 Ligand (CD30L)/TNFSF8 is a type II membrane protein belonging to the TNF superfamily. CD30L is expressed on the cell surface of activated T cells, B cells, and monocytes. The protein is also constitutively expressed on granulocytes and medullary thymic epithelial cells. The specific receptor for CD30L is CD30/TNFRSF8, a type I transmembrane glycoprotein belonging to the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkin's and Reed-Sternberg cells using the monoclonal antibody Ki-1. CD30 is also expressed on different non-Hodgkin's lymphomas, virus-infected T and B cells, and on normal T and B cells after activation. Among T cells, CD30 is preferentially expressed on a subset of T cells producing Th2-type cytokines and on CD4⁺/CD8⁺ thymocytes that coexpress CD45RO and IL-4 receptor. CD30 ligation by CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation and cell death by apoptosis. CD30 can act as a costimulatory molecule in thymic negative selection and may also play a critical role in the pathophysiology of Hodgkin's disease and other CD30⁺ lymphomas.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: Bioassay, ELISA Development, In Vivo, Western Blot.

Showing Publications 1 - 3 of 3.

Publications using 732-CL	Applications	Species
S Yoshida, H Nakagami, H Hayashi, Y Ikeda, J Sun, A Tenma, H Tomioka, T Kawano, M Shimamura, R Morishita, H Rakugi The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice Nat Commun, 2020-05-18;11(1):2482. 2020-05-18 [PMID: 32424156] (ELISA Development, Western Blot, Mouse)	ELISA Development, Western Blot	Mouse
Mahmud , Shawn A, Manlove , Luke S, Schmitz , Heather, Xing , Yan, Wang , Yanyan, Owen , David L, Schenkel , Jason M, Boomer , Jonathan, Green , Jonathan, Yagita , Hideo, Chi , Hongbo, Hogquist , Kristin, Farrar , Michael Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. Nat Immunol, 2014-03-16;15(5):473-81. 2014-03-16 [PMID: 24633226] (Bioassay, Mouse)	Bioassay	Mouse
Kayamuro H, Yoshioka Y, Abe Y, Katayama K, Yoshida T, Yamashita K, Yoshikawa T, Hiroi T, Itoh N, Kawai Y, Mayumi T, Kamada H, Tsunoda S, Tsutsumi Y TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant. Biochem. Biophys. Res. Commun., 2009-05-04;384(3):296-300. 2009-05-04 [PMID: 19406102] (In Vivo, Mouse)	In Vivo	Mouse

Array 732-CL

• CD30 Ligand/TNFSF8 Antibodies
• CD30 Ligand/TNFSF8 ELISA Kits
• CD30 Ligand/TNFSF8 Lysate
• CD30 Ligand/TNFSF8 ELISA
• CD30 Ligand/TNFSF8 Proteins and Enzymes