Recombinant Mouse BAFF/BLyS/TNFSF13B Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

B-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a 32 kDa transmembrane glycoprotein in the TNF ligand superfamily. It is involved in multiple aspects of immune system regulation, particularly towards B cells (1, 2). Mature mouse BAFF consists of a 47 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 241 aa extracellular domain (ECD) with a stalk region and one TNF-like domain (3, 4). Within aa 127-309 of the ECD, mouse BAFF shares 72% aa sequence identity with human BAFF. It can be expressed as a homotrimer or as a heteromer in association with the related TNFSF member APRIL (4, 5). A 18 kDa fragment containing the TNF-like domain can be released by proteolysis between Arg126 and Ala127 (4). Soluble BAFF is stored intracellularly in neutrophils and released upon inflammatory stimulation (6). Alternative splicing generates an isoform termed deltaBAFF that lacks 19 aa between the proteolytic cleavage site and the TNF-like domain. deltaBAFF can form heteromers with BAFF and negatively regulates BAFF function (7). BAFF is produced by many hematopoietic cell types including by monocytes, macrophages, neutrophils, dendritic cells, and T cells and also by adipocytes (1, 2, 8). Both BAFF and APRIL are functional ligands for the TNF receptor superfamily members BCMA and TACI, and BAFF additionally binds and signals through BAFF R (9, 10). All three receptors are primarily expressed by B cells (10). BAFF plays a critical role in the development and survival of B lineage cells (2, 11, 12). Mice that over-express BAFF exhibit elevated B cell numbers, increased formation and size of germinal centers, and symptoms of autoimmunity (13). Soluble BAFF is elevated in B cell malignancies, autoimmunity, and other immune disorders (1). In addition, BAFF costimulates T cell activation, promotes a Th1 biased immune response, and promotes the expansion of Treg cells (14-16). BAFF also promotes monocyte survival, proinflammatory cytokine secretion, and differentiation to macrophages (17).

We have publications tested in 3 confirmed species: Mouse, Complex Species Category, Transgenic Mouse.

We have publications tested in 5 applications: Bioassay, Cell Culture, ELISA (Standard), In vivo assay, Stimulation.

Showing Publications 1 - 10 of 35. Show All 35 Publications. Collapse Publications.

Publications using 8876-BF	Applications	Species
Steach, HR;York, AG;Skadow, MH;Chen, S;Zhao, J;Williams, KJ;Zhou, Q;Hsieh, WY;Brewer, JR;Qu, R;Shyer, JA;Harman, C;Sefik, E;Mowell, WK;Bailis, W;Cui, C;Kluger, Y;Bensinger, SJ;Craft, J;Flavell, RA; IL-4 Licenses B Cell Activation Through Cholesterol Synthesis bioRxiv : the preprint server for biology 2024-05-15 [PMID: 38798553] (Bioassay, Mouse)	Bioassay	Mouse
Lin, J;Deng, W;Liao, J;Ke, D;Cui, L;Zhong, H;Huang, K;Jiang, L;Chen, Q;Xu, F;Tang, F; BAFF deficiency aggravated optic nerve crush-induced retinal ganglion cells damage by regulating apoptosis and neuroinflammation via NF-?B-I?B? signaling International immunopharmacology 2023-12-01 [PMID: 38041956] (Bioassay, Mouse)	Bioassay	Mouse
Vashisht, M;Ge, H;John, J;McKelvey, HA;Chen, J;Chen, Z;Wang, JH; TRAF2/3 deficient B cells resist DNA damage-induced apoptosis via NF-?B2/XIAP/cIAP2 axis and IAP antagonist sensitizes mutant lymphomas to chemotherapeutic drugs Cell death & disease 2023-09-08 [PMID: 37679334] (Bioassay, Mouse)	Bioassay	Mouse
Lam, JH;Baumgarth, N; Toll-like receptor mediated inflammation directs B cells towards protective antiviral extrafollicular responses Nature communications 2023-07-05 [PMID: 37407556] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
Towriss, M;MacVicar, B;Ciernia, AV; Modelling Microglial Innate Immune Memory In Vitro: Understanding the Role of Aerobic Glycolysis in Innate Immune Memory International journal of molecular sciences 2023-05-18 [PMID: 37240311] (Bioassay, Mouse)	Bioassay	Mouse
Bilgic, SN;Domaniku, A;Toledo, B;Agca, S;Weber, BZC;Arabaci, DH;Ozornek, Z;Lause, P;Thissen, JP;Loumaye, A;Kir, S; EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia Nature 2023-05-01 [PMID: 37165186] (Bioassay, Mouse)	Bioassay	Mouse
JR Doll, ME Moreno-Fer, TE Stankiewic, JL Wayland, A Wilburn, B Weinhaus, CA Chougnet, D Giordano, M Cappellett, P Presicce, SG Kallapur, N Salomonis, T Tilburgs, S Divanovic BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth Cell Reports, 2023-04-05;42(4):112352. 2023-04-05 [PMID: 37027297] (In vivo assay, Mouse)	In vivo assay	Mouse
H Koizumi, W Fujii, C Sanjoba, Y Goto BAFF induces CXCR5 expression during B cell differentiation in bone marrow Biochemistry and Biophysics Reports, 2023-03-07;34(0):101451. 2023-03-07 [PMID: 36926279] (Bioassay, Mouse)	Bioassay	Mouse
K Kanemitsu-, M Abe, Y Nakamura, T Miyake, T Watanabe, O Yoshida, Y Koizumi, M Hirooka, Y Tokumoto, B Matsuura, M Koizumi, Y Hiasa Role of B Cell-Activating Factor in Fibrosis Progression in a Murine Model of Non-Alcoholic Steatohepatitis International Journal of Molecular Sciences, 2023;24(3):. 2023 [PMID: 36768854] (Bioassay, Mouse)	Bioassay	Mouse
K Kanemitsu-, M Abe, Y Nakamura, T Miyake, T Watanabe, O Yoshida, Y Koizumi, M Hirooka, Y Tokumoto, B Matsuura, M Koizumi, Y Hiasa Role of B Cell-Activating Factor in Fibrosis Progression in a Murine Model of Non-Alcoholic Steatohepatitis International Journal of Molecular Sciences, 2023-01-28;24(3):. 2023-01-28 [PMID: 36768854] (Bioassay, Mouse)	Bioassay	Mouse
H Satofuka, S Abe, T Moriwaki, A Okada, K Kazuki, H Tanaka, K Yamazaki, G Hichiwa, K Morimoto, H Takayama, Y Nakayama, S Hatano, Y Yada, Y Murakami, Y Baba, M Oshimura, K Tomizuka, Y Kazuki Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci Nature Communications, 2022-04-05;13(1):1841. 2022-04-05 [PMID: 35383174] (Bioassay, Mouse)	Bioassay	Mouse
L Liu, M Akkoyunlu Circulating CD138 enhances disease progression by augmenting autoreactive antibody production in a mouse model of systemic lupus erythematosus The Journal of Biological Chemistry, 2021-08-06;0(0):101053. 2021-08-06 [PMID: 34364875] (Bioassay, Mouse)	Bioassay	Mouse
J Kim, SMT Islam, F Qiao, AK Singh, M Khan, J Won, I Singh Regulation of B cell functions by S-nitrosoglutathione in the EAE model Redox Biology, 2021-06-23;45(0):102053. 2021-06-23 [PMID: 34175668] (Bioassay, Mouse)	Bioassay	Mouse
CC Chan, ITW Harley, PT Pfluger, A Trompette, TE Stankiewic, JL Allen, ME Moreno-Fer, MSMA Damen, JR Oates, PC Alarcon, JR Doll, MJ Flick, LM Flick, J Sanchez-Gu, R Mukherjee, R Karns, M Helmrath, TH Inge, SP Weisberg, SJ Pamp, DA Relman, RJ Seeley, MH Tschöp, CL Karp, S Divanovic A BAFF/APRIL axis regulates obesogenic diet-driven weight gain Nature Communications, 2021-05-18;12(1):2911. 2021-05-18 [PMID: 34006859] (Bioassay, Mouse)	Bioassay	Mouse
C Tan, R Hiwa, JL Mueller, V Vykunta, K Hibiya, M Noviski, J Huizar, JF Brooks, J Garcia, C Heyn, Z Li, A Marson, J Zikherman NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting Nat. Immunol., 2020-08-31;0(0):. 2020-08-31 [PMID: 32868928] (Bioassay, Mouse)	Bioassay	Mouse
XY Cai, Y Zhu, C Wang, XY Tang, L Han, JL Shu, XZ Zhang, FQ Liang, JR Ge, L Xu, D Mei, LL Zhang, W Wei Etanercept Inhibits B Cell Differentiation by Regulating TNFRII/TRAF2/NF-kappaB Signaling Pathway in Rheumatoid Arthritis Front Pharmacol, 2020-05-12;11(0):676. 2020-05-12 [PMID: 32477138] (Bioassay, Mouse)	Bioassay	Mouse
CT Berry, X Liu, A Myles, S Nandi, YH Chen, U Hershberg, IE Brodsky, MP Cancro, CJ Lengner, MJ May, BD Freedman BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells Cell Rep, 2020-04-14;31(2):107474. 2020-04-14 [PMID: 32294437] (Cell Culture, Mouse)	Cell Culture	Mouse
P Ramezani-R, CR Leung, JR Apgar, RC Rickert E3 Ubiquitin Ligase Fbw7 Regulates the Survival of Mature B Cells J. Immunol., 2020-01-31;0(0):. 2020-01-31 [PMID: 32005754] (Cell Culture, Mouse)	Cell Culture	Mouse
RW Wu, WS Lian, YS Chen, CW Kuo, HC Ke, CK Hsieh, SY Wang, JY Ko, FS Wang MicroRNA-29a Counteracts Glucocorticoid Induction of Bone Loss through Repressing TNFSF13b Modulation of Osteoclastogenesis Int J Mol Sci, 2019-10-17;20(20):. 2019-10-17 [PMID: 31627291] (Cell Culture, Mouse)	Cell Culture	Mouse
E Ragonnaud, K Moritoh, M Bodogai, F Gusev, S Garaud, C Chen, X Wang, T Baljinnyam, KG Becker, RW Maul, K Willard-Ga, E Rogaev, A Biragyn Tumor-derived Thymic stromal lymphopoietin expands bone marrow B-cell precursors in circulation to support metastasis Cancer Res., 2019-10-01;0(0):. 2019-10-01 [PMID: 31575547] (Bioassay, Mouse)	Bioassay	Mouse
Y Jiang, C Li, Q Wu, P An, L Huang, J Wang, C Chen, X Chen, F Zhang, L Ma, S Liu, H He, S Xie, Y Sun, H Liu, Y Zhan, Y Tao, Z Liu, X Sun, Y Hu, Q Wang, D Ye, J Zhang, S Zou, Y Wang, G Wei, Y Liu, Y Shi, Y Eugene Chi, Y Hao, F Wang, X Zhang Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses Nat Commun, 2019-07-03;10(1):2935. 2019-07-03 [PMID: 31270335] (Bioassay, Mouse)	Bioassay	Mouse
M Bolger-Mun, K Choi, JM Scurll, L Abraham, RS Chappell, D Sheen, M Dang-Lawso, X Wu, JJ Priatel, D Coombs, JA Hammer, MR Gold Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation Elife, 2019-06-03;8(0):. 2019-06-03 [PMID: 31157616] (Bioassay, Complex Species Category)	Bioassay	Complex Species Category
S Khoenkhoen, E Erikson, M Ádori, JM Stark, JL Scholz, MP Cancro, GK Pedersen, GB Karlsson H TACI expression and plasma cell differentiation are impaired in the absence of functional I?BNS Immunol. Cell Biol., 2019-01-30;0(0):. 2019-01-30 [PMID: 30597621] (Bioassay, Mouse)	Bioassay	Mouse
SW Du, HM Jacobs, T Arkatkar, DJ Rawlings, SW Jackson Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B Cells J. Immunol., 2018-10-29;0(0):. 2018-10-29 [PMID: 30373855] (Stimulation, Mouse)	Stimulation	Mouse
A Sang, T Danhorn, JN Peterson, AL Rankin, BP O'Connor, SM Leach, RM Torres, R Pelanda Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus Nat Commun, 2018-09-28;9(1):3973. 2018-09-28 [PMID: 30266981] (Bioassay, Mouse)	Bioassay	Mouse
T Matsushita, T Kobayashi, K Mizumaki, M Kano, T Sawada, M Tennichi, A Okamura, Y Hamaguchi, Y Iwakura, M Hasegawa, M Fujimoto, K Takehara BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance Sci Adv, 2018-07-11;4(7):eaas9944. 2018-07-11 [PMID: 30009261] (Bioassay, Mouse)	Bioassay	Mouse
NM Schabla, GA Perry, VL Palmer, PC Swanson VprBP (DCAF1) Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation J. Immunol., 2018-06-20;0(0):. 2018-06-20 [PMID: 29925675] (Bioassay, Mouse)	Bioassay	Mouse
HD Brightbill, E Suto, N Blaquiere, N Ramamoorth, S Sujatha-Bh, EB Gogol, GM Castanedo, BT Jackson, YC Kwon, S Haller, J Lesch, K Bents, C Everett, PB Kohli, S Linge, L Christian, K Barrett, A Jaochico, LM Berezhkovs, PW Fan, Z Modrusan, K Veliz, MJ Townsend, J DeVoss, AR Johnson, R Godemann, WP Lee, CD Austin, BS McKenzie, JA Hackney, JJ Crawford, ST Staben, MH Alaoui Ism, LC Wu, N Ghilardi NF-?B inducing kinase is a therapeutic target for systemic lupus erythematosus Nat Commun, 2018-01-12;9(1):179. 2018-01-12 [PMID: 29330524] (Bioassay, Mouse)	Bioassay	Mouse
A De Riva, M Wållberg, F Ronchi, R Coulson, A Sage, L Thorne, I Goodfellow, KD McCoy, M Azuma, A Cooke, R Busch Regulation of type 1 diabetes development and B-cell activation in nonobese diabetic mice by early life exposure to a diabetogenic environment PLoS ONE, 2017-08-03;12(8):e0181964. 2017-08-03 [PMID: 28771521] (ELISA (Standard), Mouse)	ELISA (Standard)	Mouse
JT McKay, MA Haro, CA Daly, RD Yammani, B Pang, WE Swords, KM Haas PD-L2 Regulates B-1 Cell Antibody Production against Phosphorylcholine through an IL-5-Dependent Mechanism J. Immunol., 2017-08-02;0(0):. 2017-08-02 [PMID: 28768724] (Bioassay, Mouse)	Bioassay	Mouse
S Park, H Sim, HI Kim, D Jeong, G Wu, SY Cho, YS Lee, HJ Kwon, K Lee CD11b regulates antibody class switching via induction of AID Mol. Immunol., 2017-04-11;87(0):47-59. 2017-04-11 [PMID: 28407558] (Bioassay, Mouse)	Bioassay	Mouse
M Kuraoka, PB Snowden, T Nojima, L Verkoczy, BF Haynes, D Kitamura, G Kelsoe BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance Cell Rep, 2017-02-14;18(7):1627-1635. 2017-02-14 [PMID: 28199836] (Bioassay, Mouse)	Bioassay	Mouse
J Jellusova, MH Cato, JR Apgar, P Ramezani-R, CR Leung, C Chen, AD Richardson, EM Conner, RJ Benschop, JR Woodgett, RC Rickert Gsk3 is a metabolic checkpoint regulator in B cells Nat. Immunol, 2017-01-23;0(0):. 2017-01-23 [PMID: 28114292] (Bioassay, Mouse)	Bioassay	Mouse
Peishan Lee Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation J. Immunol, 2016-12-28;0(0):. 2016-12-28 [PMID: 28031341] (Bioassay, Mouse)	Bioassay	Mouse
Uslu K, Coleman A, Allman W, Katsenelson N, Bram R, Alugupalli K, Akkoyunlu M Impaired B cell receptor signaling is responsible for reduced TACI expression and function in X-linked immunodeficient mice. J Immunol, 2014-03-19;192(8):3582-95. 2014-03-19 [PMID: 24646744] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
Show All 35 Publications. Collapse Publications.

Array 8876-BF

• BAFF/BLyS/TNFSF13B Antibodies
• BAFF/BLyS/TNFSF13B Antibody Pair
• BAFF/BLyS/TNFSF13B ELISA Kit
• BAFF/BLyS/TNFSF13B Lysate
• BAFF/BLyS/TNFSF13B Proteins
• BAFF/BLyS/TNFSF13B Proteins and Enzymes
• BAFF/BLyS/TNFSF13B ELISAs