Recombinant Human uPAR Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

uPAR (urokinase-type plasminogen activator receptor, also known as CD87), is a cell surface receptor that binds urokinase-type plasminogen activator (uPA) which cleaves the zymogen plasminogen to form the active enzyme plasmin. uPAR expression is activated during inflammation, immune responses, and conditions of tissue remodeling and wound healing (1). Human uPAR is synthesized as a 335 amino acid (aa) residue precursor protein with a 22 aa signal peptide. Removal of the C-terminal propeptide generates a fully processed uPAR containing 283 aa with five potential N-linked glycosylation sites and a C-terminal GPI-anchor site (2). Variants due to alternative splicing of uPAR also exist (3). Human and mouse uPAR share approximately 60% aa sequence identity and the receptor-ligand interaction is strictly species-specific (4). The uPA/uPAR interaction initiates signal transduction responses resulting in activation of protein tyrosine kinases, gene expression, cell adhesion, and chemotaxis. uPAR can interact with integrins to suppress normal integrin adhesive function and promote adhesion to vitronectin through a high affinity vitronectin binding site on uPAR. uPAR is considered as a biomarker in many inflammatory diseases including cancer, cardiovascular diseases, chronic kidney diseases and diabetes (5).

Array 10378-UK

• uPAR Antibodies
• uPAR Antibody Pair
• uPAR Lysate
• uPAR Proteins
• uPAR Proteins and Enzymes
• uPAR ELISAs