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Recombinant Human Stanniocalcin 1/STC-1 Protein, CF

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Bioactivity
Format
Carrier-Free

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Recombinant Human Stanniocalcin 1/STC-1 Protein, CF Summary

Details of Functionality
Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. The ED50 for this effect is 20-120 ng/mL in the presence of 10 ng/mL of Recombinant Mouse Wnt-3a (Catalog # 1324-WN) .
Source
Mouse myeloma cell line, NS0-derived human Stanniocalcin 1/STC-1 protein
Thr18-Ala247, with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Thr18
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Bioactivity
Theoretical MW
27 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
26-43 kDa, reducing conditions
Publications
Read Publications using
9400-SO in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 500 μg/mL in PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Stanniocalcin 1/STC-1 Protein, CF

  • Stanniocalcin 1
  • stanniocalcin-1
  • STC1
  • STC-1
  • STCSTC-1

Background

Stanniocalcin 1 (STC-1) is a homodimeric glycoprotein hormone that is involved in calcium and phosphate homeostasis. It was originally identified in bony fishes, where elevation of calcium in serum causes the release of STC from the endocrine glands called the corpuscles of Stannius (1-3). In contrast to fish where expression is mainly in the corpuscles of Stannius, the STC-1 gene in mammals is widely expressed in tissues including thyroid, ovary, prostate, adrenal gland, muscle, intestine, kidney, heart and lung (4). Human STC-1 protein consists of a 16 amino acid (aa) propeptide region and a 214 aa STC-1 chain. The amino acid sequence of human mature STC-1 is 36% identical to that of human STC-2. STC-1 is highly homologous with mouse, sharing 95% amino acid identity. STC-1 inhibits the breakdown of PAPP-A (5), protects cancer cells from apoptosis (4), reduces tumor size of liver cancers (6), promotes osteoblast differentiation (7) and inhibits longitudinal bone growth directly at the growth plate (8). It is also a biomarker of brain and lung cancer progression (7, 8).
  1. Yoshiko, Y. and J.E. Aubin. (2004) Peptides 25:1663.
  2. Wendelaar Bonga S.E. and P.K. Pang (1991) Int. Rev. Cytol. 128:139.
  3. Wascher, R.A. et al. (2003) Clin. Cancer Res. 9:1427.
  4. ­Ohkouchi, S. et al. (2015) Clin. Med. Insights Circ. Respir. Pulm. Med. 9:91.
  5. Kloverpris S, et al. (2015) J Biol Chem. 290:21915.
  6. Yeung BH, et al. (2015) PLoS One. 10:e0139977.
  7. Su J, et al. (2015) Tumour Biol. 36:6333.
  8. Du YZ, et al. (2016) Tumour Biol. 37:5633.

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Publications for Stanniocalcin 1/STC-1 (9400-SO)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Bioassay.


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(2)
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(2)
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